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Comment
. 2023 Apr 14;4(4):220-222.
doi: 10.1016/j.medj.2023.03.005.

Utrophin correlates with disease severity in Duchenne muscular dystrophy

Simon Guiraud  1 , Kay Davies  2
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Utrophin correlates with disease severity in Duchenne muscular dystrophy

Simon Guiraud et al. Med. .
Free article

Abstract

This month in Med, the description of an unusually severely affected DMD patient suffering from a large deletion in the dystrophin gene confirms that absence of utrophin worsens the dystrophy and supports the concept that utrophin upregulation ameliorates the pathology. This study may guide the development of dystrophin-based gene therapies.

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Conflict of interest statement

Declarations of interest The authors declare no competing interests.

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