Higher-dose dexamethasone for patients with COVID-19 and hypoxaemia?
- PMID: 37060914
- PMCID: PMC10097504
- DOI: 10.1016/S0140-6736(23)00587-1
Higher-dose dexamethasone for patients with COVID-19 and hypoxaemia?
Conflict of interest statement
AP and BV were investigators on the COVID STEROID 2 trial, which was funded by the Novo Nordisk Foundation. AP receives research funding from the Novo Nordisk Foundation and Sygeforsikringen danmark, and has received honorarium from Novartis for participating on an advisory board. The Department of Intensive Care, Rigshospitalet has received funding for research from Pfizer within the past 3 years and has done contract research for AM-Pharma. BV is supported by a National Health and Medical Research Council Investigator Research Fellowship and has received institutional research support from Baxter.
Comment on
-
Higher dose corticosteroids in patients admitted to hospital with COVID-19 who are hypoxic but not requiring ventilatory support (RECOVERY): a randomised, controlled, open-label, platform trial.Lancet. 2023 May 6;401(10387):1499-1507. doi: 10.1016/S0140-6736(23)00510-X. Epub 2023 Apr 13. Lancet. 2023. PMID: 37060915 Free PMC article. Clinical Trial.
Similar articles
-
High-flow nasal oxygen: benefits are hard to show in COVID-19 patients with mild hypoxaemia.Thorax. 2023 Apr;78(4):321-322. doi: 10.1136/thorax-2022-219156. Epub 2022 Dec 8. Thorax. 2023. PMID: 36598078 No abstract available.
-
Heterogeneous treatment effects of dexamethasone 12 mg versus 6 mg in patients with COVID-19 and severe hypoxaemia-Post hoc exploratory analyses of the COVID STEROID 2 trial.Acta Anaesthesiol Scand. 2023 Feb;67(2):195-205. doi: 10.1111/aas.14167. Epub 2022 Nov 8. Acta Anaesthesiol Scand. 2023. PMID: 36314057 Free PMC article. Clinical Trial.
-
Long-term outcomes of dexamethasone 12 mg versus 6 mg in patients with COVID-19 and severe hypoxaemia.Intensive Care Med. 2022 May;48(5):580-589. doi: 10.1007/s00134-022-06677-2. Epub 2022 Mar 31. Intensive Care Med. 2022. PMID: 35359168 Free PMC article. Clinical Trial.
-
Dexamethasone: Therapeutic potential, risks, and future projection during COVID-19 pandemic.Eur J Pharmacol. 2021 Mar 5;894:173854. doi: 10.1016/j.ejphar.2021.173854. Epub 2021 Jan 8. Eur J Pharmacol. 2021. PMID: 33428898 Free PMC article. Review.
-
The effectiveness of dexamethasone as a combination therapy for COVID-19.Acta Pharm. 2022 Apr 13;72(3):345-358. doi: 10.2478/acph-2022-0030. Print 2022 Sep 1. Acta Pharm. 2022. PMID: 36651541 Review.
Cited by
-
COVID-19: An Update on Epidemiology, Prevention and Treatment, September-2023.Infect Dis Clin Microbiol. 2023 Sep 30;5(3):165-187. doi: 10.36519/idcm.2023.251. eCollection 2023 Sep. Infect Dis Clin Microbiol. 2023. PMID: 38633552 Free PMC article. Review.
-
Comparative Efficacy of High-Dose Dexamethasone Versus Methylprednisolone in Coronavirus Disease 2019 (COVID-19)-Associated Acute Respiratory Distress Syndrome.Cureus. 2024 Mar 7;16(3):e55725. doi: 10.7759/cureus.55725. eCollection 2024 Mar. Cureus. 2024. PMID: 38586644 Free PMC article.
-
Immunity and Coagulation in COVID-19.Int J Mol Sci. 2024 Oct 19;25(20):11267. doi: 10.3390/ijms252011267. Int J Mol Sci. 2024. PMID: 39457048 Free PMC article. Review.
References
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical