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. 2023 Jul;87(1):62-63.
doi: 10.1016/j.jinf.2023.04.005. Epub 2023 Apr 13.

SARS-CoV-2 variant-dependent inflammasome activation

Elisa Teyssou  1 , Stéphane Marot  2 , Adélie Gothland  2 , Isabelle Malet  2 , Karen Zafilaza  2 , Valentin Leducq  2 , Théophile Cocherie  2 , Eve Todesco  2 , Cathia Soulié  2 , Anne-Geneviève Marcelin  2 , Vincent Calvez  2
Affiliations

SARS-CoV-2 variant-dependent inflammasome activation

Elisa Teyssou et al. J Infect. 2023 Jul.
No abstract available

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Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
SARS-CoV-2 variants-dependent IL-1β secretion in macrophage-like THP-1 cells. A) Supernatant relative viral load of differentiated-THP-1 cells infected by the SARS-CoV-2 historical strain after 4 and 24 h post infection at an MOI of 0.1 indicative of a permissive infection. B) Histograms represent IL-1β quantification in supernatants of non- (mock) or SARS-CoV-2 infected cells. Nigericin is used as positive control for NLRP-3 activation in differentiated-THP-1 cells. *p < 0.05; ****p < 0.0001. Data shown result from multiple independent experiments.
See this image and copyright information in PMC

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Supplementary concepts