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Review
. 2023:48:71-108.
doi: 10.1016/bs.podrm.2022.11.003. Epub 2023 Feb 9.

Remdesivir

Ahmed H Bakheit  1 , Hany Darwish  2 , Ibrahim A Darwish  2 , Ahmed I Al-Ghusn  2
Affiliations
Review

Remdesivir

Ahmed H Bakheit et al. Profiles Drug Subst Excip Relat Methodol. 2023.

Abstract

Remdesivir, marketed under the brand name Veklury, is an antiviral drug with a broad spectrum of activity. There were various countries where the use of Remdesivir for the treatment of COVID-19 was authorized during the pandemic. Remdesivir was first designed to treat hepatitis C, but it was later tested for Ebola virus sickness and Marburg virus infections. Remdesivir is a prodrug designed to facilitate the intracellular transport of GS-441524 monophosphate and its subsequent biotransformation into GS-441524 triphosphate, a ribonucleotide analogue inhibitor of viral RNA polymerase. The objective of this chapter is to provide a comprehensive review of Remdesivir (GS-5734), including its nomenclature, physiochemical properties, preparation methods, identification procedures, numerous qualitative and quantitative analytical techniques, ADME profiles, and pharmacological effects. In addition, the chapter provides a variety of chromatographic and spectroscopic techniques for separating brimonidine from other drugs in combination formulations.

Keywords: (GS-5734); Antiviral drug; COVID-19; Clinical pharmacology; GS-441524 monophosphate; HPLC, methods of preparation; Remdesivir; Spectrometric analysis.

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Figures

Fig. 1
Fig. 1
Chemical structure of Remdesivir.
Scheme 1
Scheme 1
Siegel route for synthesis of Remdesivir.
Scheme 2
Scheme 2
(A) Synthesis of a single Sp isomer 8 from a p-nitrophenolate prodrug precursor 10 instead of phenyl phosphorodichloridate afforded. (B) Gilead route for the synthesis of Remdesivir (1, GS-5734).
Scheme 3
Scheme 3
(A) Synthesis of 5-O-TBDPS-2,3-O-diallyl ribonolactone 5. (B) Total synthesis of remdesivir (1, GS-5734).
Fig. 2
Fig. 2
Thermogravimetric analysis (TGA) of Remdesivir.
Fig. 3
Fig. 3
The UV-absorption spectrum of 20 μg/mL of Remdesivir in methanol.
Fig. 4
Fig. 4
The fluorescence spectrum excitation and emission of Remdesivir in methanol.
Fig. 5
Fig. 5
IR spectrum of Remdesivir.
Fig. 6
Fig. 6
1H NMR spectrum of Remdesivir.
Fig. 7
Fig. 7
Full scan mass spectra of Remdesivir.
Fig. 8
Fig. 8
Product ion spectra of Remdesivir.
Fig. 9
Fig. 9
Intracellular metabolic pathway of Remdesivir.
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References

    1. Malin J.J., Suárez I., Priesner V., Fätkenheuer G., Rybniker J. Remdesivir against COVID-19 and other viral diseases. Clin. Microbiol. Rev. 2020;34(1) p. e00162-20. - PMC - PubMed
    1. Pashaei Y. Analytical methods for the determination of remdesivir as a promising antiviral candidate drug for the COVID-19 pandemic. Drug Discov. Ther. 2021;14(6):273–281. - PubMed
    1. Remdesivir (Compound) 2022. https://pubchem.ncbi.nlm.nih.gov/compound/121304016#section=3D-Conformer [cited 2022 24 March]; from.
    1. Remdesivir (HMDB0304869) The Metabolomics Innovation Centre (TMIC) 2022. https://hmdb.ca/metabolites/HMDB0304869 [cited 2022 24 March]; from.
    1. Remdesivir The Merck Index Online 2022. 2022. https://www.rsc.org/Merck-Index/monograph/m12252/remdesivir?q=unauthorize [cited 2022 24 March]; from.