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Review
. 2023 Jun;42(2):575-587.
doi: 10.1007/s10555-023-10107-0. Epub 2023 Apr 15.

Colorectal cancer liver metastasis: genomic evolution and crosstalk with the liver microenvironment

Qiu-Luo Liu #  1 , Huijie Zhou #  2 , Zong-Guang Zhou  1 , Hai-Ning Chen  3
Affiliations
Review

Colorectal cancer liver metastasis: genomic evolution and crosstalk with the liver microenvironment

Qiu-Luo Liu et al. Cancer Metastasis Rev. 2023 Jun.

Abstract

Colorectal cancer (CRC) patients frequently develop liver metastases, which are the major cause of cancer-related mortality. The molecular basis and management of colorectal liver metastases (CRLMs) remain a challenging clinical issue. Recent genomic evidence has demonstrated the liver tropism of CRC and the presence of a stricter evolutionary bottleneck in the liver as a target organ compared to lymph nodes. This bottleneck challenging CRC cells in the liver is organ-specific and requires adaptation not only at the genetic level, but also at the phenotypic level to crosstalk with the hepatic microenvironment. Here, we highlight the emerging evidence on the clonal evolution of CRLM and review recent insights into the molecular mechanisms orchestrating the bidirectional interactions between metastatic CRC cells and the unique liver microenvironment.

Keywords: Colorectal cancer liver metastasis; Genomic evolution; Tumor immune microenvironment; Tumor metabolism; Tumor microenvironment.

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