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. 2023 Apr 15;24(1):112.
doi: 10.1186/s12931-023-02413-6.

Systematic review of overlapping microRNA patterns in COVID-19 and idiopathic pulmonary fibrosis

Julien Guiot  1   2 , Monique Henket  1 , Claire Remacle  1   3 , Maureen Cambier  1   3 , Ingrid Struman  3 , Marie Winandy  1 , Catherine Moermans  1 , Edouard Louis  4   2 , Michel Malaise  5   2 , Clio Ribbens  5   2 , Renaud Louis  1   2 , Makon-Sébastien Njock  6   7
Affiliations

Systematic review of overlapping microRNA patterns in COVID-19 and idiopathic pulmonary fibrosis

Julien Guiot et al. Respir Res. .

Abstract

Background: Pulmonary fibrosis is an emerging complication of SARS-CoV-2 infection. In this study, we speculate that patients with COVID-19 and idiopathic pulmonary fibrosis (IPF) may share aberrant expressed microRNAs (miRNAs) associated to the progression of lung fibrosis.

Objective: To identify miRNAs presenting similar alteration in COVID-19 and IPF, and describe their impact on fibrogenesis.

Methods: A systematic review of the literature published between 2010 and January 2022 (PROSPERO, CRD42022341016) was conducted using the key words (COVID-19 OR SARS-CoV-2) AND (microRNA OR miRNA) or (idiopathic pulmonary fibrosis OR IPF) AND (microRNA OR miRNA) in Title/Abstract.

Results: Of the 1988 references considered, 70 original articles were appropriate for data extraction: 27 studies focused on miRNAs in COVID-19, and 43 on miRNAs in IPF. 34 miRNAs were overlapping in COVID-19 and IPF, 7 miRNAs presenting an upregulation (miR-19a-3p, miR-200c-3p, miR-21-5p, miR-145-5p, miR-199a-5p, miR-23b and miR-424) and 9 miRNAs a downregulation (miR-17-5p, miR-20a-5p, miR-92a-3p, miR-141-3p, miR-16-5p, miR-142-5p, miR-486-5p, miR-708-3p and miR-150-5p).

Conclusion: Several studies reported elevated levels of profibrotic miRNAs in COVID-19 context. In addition, the balance of antifibrotic miRNAs responsible of the modulation of fibrotic processes is impaired in COVID-19. This evidence suggests that the deregulation of fibrotic-related miRNAs participates in the development of fibrotic lesions in the lung of post-COVID-19 patients.

Keywords: COVID-19; Idiopathic pulmonary fibrosis; Post-COVID-19 lung fibrosis; microRNA.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential competing interests.

Figures

Fig. 1
Fig. 1
Flow diagram of the systematic research method for detecting matching miRNAs in COVID-19 and IPF
Fig. 2
Fig. 2
Overlapping of dysregulated miRNAs in COVID-19 and IPF: impact in the development of fibrotic lesions in the lung of post-COVID-19 patients
See this image and copyright information in PMC

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