Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Apr 15;24(1):112.
doi: 10.1186/s12931-023-02413-6.

Systematic review of overlapping microRNA patterns in COVID-19 and idiopathic pulmonary fibrosis

Julien Guiot  1   2 , Monique Henket  1 , Claire Remacle  1   3 , Maureen Cambier  1   3 , Ingrid Struman  3 , Marie Winandy  1 , Catherine Moermans  1 , Edouard Louis  4   2 , Michel Malaise  5   2 , Clio Ribbens  5   2 , Renaud Louis  1   2 , Makon-Sébastien Njock  6   7
Affiliations

Systematic review of overlapping microRNA patterns in COVID-19 and idiopathic pulmonary fibrosis

Julien Guiot et al. Respir Res. .

Abstract

Background: Pulmonary fibrosis is an emerging complication of SARS-CoV-2 infection. In this study, we speculate that patients with COVID-19 and idiopathic pulmonary fibrosis (IPF) may share aberrant expressed microRNAs (miRNAs) associated to the progression of lung fibrosis.

Objective: To identify miRNAs presenting similar alteration in COVID-19 and IPF, and describe their impact on fibrogenesis.

Methods: A systematic review of the literature published between 2010 and January 2022 (PROSPERO, CRD42022341016) was conducted using the key words (COVID-19 OR SARS-CoV-2) AND (microRNA OR miRNA) or (idiopathic pulmonary fibrosis OR IPF) AND (microRNA OR miRNA) in Title/Abstract.

Results: Of the 1988 references considered, 70 original articles were appropriate for data extraction: 27 studies focused on miRNAs in COVID-19, and 43 on miRNAs in IPF. 34 miRNAs were overlapping in COVID-19 and IPF, 7 miRNAs presenting an upregulation (miR-19a-3p, miR-200c-3p, miR-21-5p, miR-145-5p, miR-199a-5p, miR-23b and miR-424) and 9 miRNAs a downregulation (miR-17-5p, miR-20a-5p, miR-92a-3p, miR-141-3p, miR-16-5p, miR-142-5p, miR-486-5p, miR-708-3p and miR-150-5p).

Conclusion: Several studies reported elevated levels of profibrotic miRNAs in COVID-19 context. In addition, the balance of antifibrotic miRNAs responsible of the modulation of fibrotic processes is impaired in COVID-19. This evidence suggests that the deregulation of fibrotic-related miRNAs participates in the development of fibrotic lesions in the lung of post-COVID-19 patients.

Keywords: COVID-19; Idiopathic pulmonary fibrosis; Post-COVID-19 lung fibrosis; microRNA.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential competing interests.

Figures

Fig. 1
Fig. 1
Flow diagram of the systematic research method for detecting matching miRNAs in COVID-19 and IPF
Fig. 2
Fig. 2
Overlapping of dysregulated miRNAs in COVID-19 and IPF: impact in the development of fibrotic lesions in the lung of post-COVID-19 patients
See this image and copyright information in PMC

References

    1. WHO Coronavirus (COVID-19) Dashboard. 2022. https://covid19.who.int. Accessed 25 May 2022.
    1. Hasan SS, Capstick T, Ahmed R, Kow CS, Mazhar F, Merchant H, et al. Mortality in COVID-19 patients with acute respiratory distress syndrome and corticosteroids use: a systematic review and meta-analysis. Expert Rev Respir Med. 2020;14:1149–1163. doi: 10.1080/17476348.2020.1804365. - DOI - PMC - PubMed
    1. Cascella M, Rajnik M, Aleem A, Dulebohn SC, Di Napoli R. Features, evaluation, and treatment of Coronavirus (COVID-19) In: Cascella M, Rajnik M, Aleem A, Dulebohn SC, Di Napoli R, editors. StatPearls. Treasure Island: StatPearls publishing; 2020. - PubMed
    1. Grasselli G, Zangrillo A, Zanella A, Antonelli M, Cabrini L, Castelli A, et al. Baseline characteristics and outcomes of 1591 patients infected with SARS-CoV-2 admitted to ICUs of the Lombardy region, Italy. JAMA. 2020;323:1574–1581. doi: 10.1001/jama.2020.5394. - DOI - PMC - PubMed
    1. Sanyaolu A, Okorie C, Marinkovic A, Patidar R, Younis K, Desai P, et al. Comorbidity and its Impact on Patients with COVID-19. SN Compr Clin Med. 2020;2:1069–1076. doi: 10.1007/s42399-020-00363-4. - DOI - PMC - PubMed

Publication types