Conflict of interest H.G.C.V. receives grant support from the Canadian Institutes of Health Research and Heart and Stroke Foundation of Canada and has received educational program grants from Novartis and Boehringer Ingelheim. G.C.F. reports consulting for Abbott, Amgen, AstraZeneca, Bayer, Cytokinetics, Eli Lilly, Janssen, Medtronic, Merck, Novartis, and Pfizer. C.B.G. receives consulting fees for the following companies: Abbvie, Abiomed, Alnylam Pharmaceuticals, Anthos, Bayer Corporation, Boehringer Ingelheim, Boston Scientific Corporation, Bristol Myers Squibb, Cardionomics, CeleCor Therapeutics, Janssen Pharmaceutical, Merck, Novo Nordisk, Novartis Pharmaceutical Company, Pfizer, Philips, REATA, NephroSynergy. He also has salary funded by Duke grants sponsored by: Boehinger Ingelheim, Bristol Myers Squibb, Daiichi Sankyo, Food and Drug Administration, Janssen Pharmaceuticals, Novartis Pharmaceutical Company, Pfizer, and Philips. He has Equity in Tenac.io. M.B.J. reports no conflict of interest.