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Case Reports
. 2023 Dec 1;62(23):3555-3558.
doi: 10.2169/internalmedicine.1364-22. Epub 2023 Apr 14.

Adult-onset Periodic Fever, Aphthous Stomatitis, Pharyngitis and Cervical Adenitis Syndrome Responsive to Colchicine

Tsukasa Nozu  1   2 , Masumi Ohhira  3 , Masatomo Ishioh  4 , Toshikatsu Okumura  3   4
Affiliations
Case Reports

Adult-onset Periodic Fever, Aphthous Stomatitis, Pharyngitis and Cervical Adenitis Syndrome Responsive to Colchicine

Tsukasa Nozu et al. Intern Med. .

Abstract

We herein report a rare case of periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (PFAPA) syndrome that occurred in an 18-year-old man. He visited our hospital with recurrent episodes of a fever, pharyngitis and adenitis without suggestive findings of infection. These episodes resolved within 5 days and recurred quite regularly, with an interval of about 30 days. As the febrile episodes significantly impaired his quality of life, he was treated with colchicine (0.5 mg) as prophylaxis. This completely prevented the episodes during six months of follow-up. Colchicine may therefore be effective in cases of adult-onset PFAPA syndrome.

Keywords: PFAPA syndrome; adult-onset; colchicine.

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Conflict of interest statement

The authors state that they have no Conflict of Interest (COI).

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References

    1. Gaggiano C, Rigante D, Sota J, Grosso S, Cantarini L. Treatment options for periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome in children and adults: a narrative review. Clin Rheumatol 38: 11-17, 2019. - PubMed
    1. Gattorno M, Hofer M, Federici S, et al. . Classification criteria for autoinflammatory recurrent fevers. Ann Rheum Dis 78: 1025-1032, 2019. - PubMed
    1. Kolly L, Busso N, von Scheven-Gete A, et al. . Periodic fever, aphthous stomatitis, pharyngitis, cervical adenitis syndrome is linked to dysregulated monocyte IL-1β production. J Allergy Clin Immunol 131: 1635-1643, 2013. - PubMed
    1. Stojanov S, Lapidus S, Chitkara P, et al. . Periodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA) is a disorder of innate immunity and Th1 activation responsive to IL-1 blockade. Proc Natl Acad Sci U S A 108: 7148-7153, 2011. - PMC - PubMed
    1. Lachmann HJ. Periodic fever syndromes. Best Pract Res Clin Rheumatol 31: 596-609, 2017. - PubMed

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