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Review
. 2023 Mar 2:19:100599.
doi: 10.1016/j.mtbio.2023.100599. eCollection 2023 Apr.

Bone adhesive materials: From bench to bedside

Hatice B Bingol  1   2 , Johan C M E Bender  2 , Joost A Opsteen  2 , Sander C G Leeuwenburgh  1
Affiliations
Review

Bone adhesive materials: From bench to bedside

Hatice B Bingol et al. Mater Today Bio. .

Abstract

Biodegradable bone adhesives represent a highly sought-after type of biomaterial which would enable replacement of traditional metallic devices for fixation of bone. However, these biomaterials should fulfil an extremely large number of requirements. As a consequence, bone-adhesive biomaterials which meet all of these requirements are not yet commercially available. Therefore, this comprehensive review provides an extensive overview of the development of bone adhesives from a translational perspective. First, the definition, classification, and chemistry of various types of bone adhesives are highlighted to provide a detailed overview of this emerging class of biomaterials. In this review we particularly focused studies which describe the use of materials that are capable of gluing two pieces of bone together within a time frame of minutes to days. Second, this review critically reflects on i) the experimental conditions of commonly employed adhesion tests to assess bone adhesion and ii) the current state-of-the-art regarding their preclinical and clinical applicability.

Keywords: Biomaterials; Bone adhesive; Bone fracture; Bone glue; Orthopedic surgery.

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Conflict of interest statement

The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Hatice B. Bingol reports financial support was provided by 10.13039/501100004410Scientific and Technological Research Council of Turkey. Sander C.G. Leeuwenburgh reports a relationship with GATT Technologies that includes: board membership. Joost A. Opsteen reports a relationship with GATT Technologies that includes: employment. Hatice B. Bingol reports a relationship with GATT Technoogies that includes: employment. Johan C.M.E. Bender is the founder of GATT Technologies. GATT Technologies has patent applications on bone adhesive materials. Since this manuscript is a review paper and not a research paper, the patent applications are not directly related to the submitted work.

Figures

Image 1
Graphical abstract
Fig. 1
Fig. 1
Application of a bone adhesive for bone fracture repair.
Fig. 2
Fig. 2
Chemical composition of bone adhesives.
Fig. 3
Fig. 3
Ex-vivo and in vivo testing of bone adhesives. Reproduced with permission [36] Copyright 2021, The John Wiley & Sons.
See this image and copyright information in PMC

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