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Review
. 2023 Mar 31:14:1162045.
doi: 10.3389/fphar.2023.1162045. eCollection 2023.

Non-coding RNAs: The recently accentuated molecules in the regulation of cell autophagy for ovarian cancer pathogenesis and therapeutic response

Bi Peng  1 , Jing Li  2 , Yuanliang Yan  3 , Yuanhong Liu  3 , Qiuju Liang  3   4 , Wei Liu  1   5 , Abhimanyu Thakur  6 , Kui Zhang  7 , Zhijie Xu  1 , Jian Wang  2 , Fan Zhang  8
Affiliations
Review

Non-coding RNAs: The recently accentuated molecules in the regulation of cell autophagy for ovarian cancer pathogenesis and therapeutic response

Bi Peng et al. Front Pharmacol. .

Abstract

Autophagy is a self-recycling and conserved process, in which the senescent cytoplasmic components are degraded in cells and then recycled to maintain homeostatic balance. Emerging evidence has suggested the involvement of autophagy in oncogenesis and progression of various cancers, such as ovarian cancer (OC). Meanwhile, the non-coding RNAs (ncRNAs) frequently regulate the mRNA transcription and other functional signaling pathways in cell autophagy, displaying promising roles in human cancer pathogenesis and therapeutic response. This article mainly reviews the cutting-edge research advances about the interactions between ncRNAs and autophagy in OC. This review not only summarizes the underlying mechanisms of dynamic ncRNA-autophagy association in OC, but also discusses their prognostic implications and therapeutic biomarkers. The aim of this review was to provide a more in-depth knowledge framework exploring the ncRNA-autophagy crosstalk and highlight the promising treatment strategies for OC patients.

Keywords: cancer pathogenesis; cell autophagy; non-coding RNAs; ovarian cancer; prognosis.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Overview of autophagy process.
FIGURE 2
FIGURE 2
Roles of miRNAs in autophagy regulation in OC.
FIGURE 3
FIGURE 3
Roles of lncRNAs in autophagy regulation in OC.
See this image and copyright information in PMC

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