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Review
. 2023 Mar 16:28:17.
doi: 10.4103/jrms.jrms_781_21. eCollection 2023.

Prevalence and associated factors of mortality after percutaneous coronary intervention for adult patients with ST-elevation myocardial infarction: A systematic review and meta-analysis

Fanghong Yan  1   2 , Yuanyuan Zhang  3 , Yayan Pan  1 , Sijun Li  4 , Mengqi Yang  1 , Yutan Wang  5 , Chen Yanru  1 , Wenli Su  1 , Yuxia Ma  1 , Lin Han  1   2   6
Affiliations
Review

Prevalence and associated factors of mortality after percutaneous coronary intervention for adult patients with ST-elevation myocardial infarction: A systematic review and meta-analysis

Fanghong Yan et al. J Res Med Sci. .

Abstract

Background: There is a paucity of systematic reviews on the associated factors of mortality among ST-elevation myocardial infarction (STEMI) patients after percutaneous coronary intervention (PCI). This meta-analysis was designed to synthesize available evidence on the prevalence and associated factors of mortality after PCI for adult patients with STEMI.

Materials and methods: Databases including the Cochrane Library, PubMed, Web of Science, Embase, Ovid, Scopus, ProQuest, MEDLINE, and CINAHL Complete were searched systematically to identify relevant articles published from January 2008 to March 2020 on factors affecting mortality after PCI in STEMI patients. Meta-analysis was conducted using Stata 12.0 software package.

Results: Our search yielded 91 cohort studies involving a total of 199, 339 participants. The pooled mortality rate for STEMI patients after PCI was 10%. After controlling for grouping criteria or follow-up time, the following 17 risk factors were significantly associated with mortality for STEMI patients after PCI: advanced age (odds ratio [OR] = 3.89), female (OR = 2.01), out-of-hospital cardiac arrest (OR = 5.55), cardiogenic shock (OR = 4.83), renal dysfunction (OR = 3.50), admission anemia (OR = 3.28), hyperuricemia (OR = 2.71), elevated blood glucose level (OR = 2.00), diabetes mellitus (OR = 1.8), chronic total occlusion (OR = 2.56), Q wave (OR = 2.18), without prodromal angina (OR = 2.12), delay in door-to-balloon time (OR = 1.72), delay in symptom onset-to-balloon time (OR = 1.43), anterior infarction (OR = 1.66), ST-segment resolution (OR = 1.40), and delay in symptom onset-to-door time (OR = 1.29).

Conclusion: The pooled prevalence of mortality after PCI for STEMI patients was 10%, and 17 risk factors were significantly associated with mortality for STEMI patients after PCI.

Keywords: Meta-analysis; ST-elevation myocardial infarction; mortality; percutaneous coronary intervention.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Flowchart of study selection
Figure 2
Figure 2
The pooled mortality rate for STEMI patients after PCI. STEMI = ST-elevation myocardial infarction; PCI = Percutaneous coronary intervention
Figure 3
Figure 3
Funnel plot for assessing publication biases
Figure 4
Figure 4
Comparison of grouping criteria of NLR according to mortality. NLR = neutrophils to lymphocytes
See this image and copyright information in PMC

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