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Case Reports
. 2022 Jul 26;15(1):159-161.
doi: 10.1055/s-0042-1750079. eCollection 2023 Mar.

Cystic Pancreatic Neuroendocrine Tumor: A Diagnostic Dilemma

Md Ali Osama  1 , Meera Mathayoth  2 , Shilpi Agarwal  1 , Priti Chatterjee  1
Affiliations
Case Reports

Cystic Pancreatic Neuroendocrine Tumor: A Diagnostic Dilemma

Md Ali Osama et al. J Lab Physicians. .

Abstract

Pancreatic neuroendocrine tumors are typically solid neoplasms but in rare instances may present as cystic lesions. Preoperative diagnosis of a cystic pancreatic lesion is challenging and requires a multidisciplinary and multimodal approach. We hereby describe an elderly female who came with complaints of abdominal lump. Radiologically, it appeared to be a pancreatic hydatid cyst located at the head of the pancreas, following which resection was done. Histopathological study of the lesion turned out to be a cystic pancreatic neuroendocrine tumor. Thus, we present this unique case due to its rarity and diagnostic challenge.

Keywords: chromogranin; cystic lesion; neuroendocrine tumor; pancreas; synaptophysin.

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Conflict of interest statement

Conflict of Interest None declared.

Figures

Fig. 1
Fig. 1
( A ) Gross image of solid-cystic pancreatic mass with a single central unilocular cyst; ( B ) gross image of opened cyst with a smooth and shiny internal surface.
Fig. 2
Fig. 2
( A ) Well-circumscribed, encapsulated tumor with rim of normal pancreatic parenchyma at the periphery ( arrow ) (H&E 100× ); ( B, C ) central cystic area delineated by fibrocollagenous tissue from the layer of neoplastic cells arranged in sheets (H&E 100× ); ( D ) cellular tumor composed of monotonous population of medium-sized polygonal cells (H&E 200× ); ( E ) IHC staining: synaptophysin positive (100× ); ( F ) IHC staining: low Ki67 proliferative index (200× ). IHC, immunohistochemistry.
See this image and copyright information in PMC

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