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. 2023 Mar 30:14:1148203.
doi: 10.3389/fendo.2023.1148203. eCollection 2023.

Association of long-term triglyceride-glucose index level and change with the risk of cardiometabolic diseases

Wenqi Xu  1   2 , Haiyan Zhao  1 , Lishu Gao  3 , Lu Guo  1   2 , Jianrong Liu  1 , Haixia Li  1 , Junyan Sun  1 , Aijun Xing  1 , Shuohua Chen  1 , Shouling Wu  1 , Yuntao Wu  1
Affiliations

Association of long-term triglyceride-glucose index level and change with the risk of cardiometabolic diseases

Wenqi Xu et al. Front Endocrinol (Lausanne). .

Abstract

Objective: The triglyceride-glucose (TyG) index is considered as a pivotal factor for various metabolic, cardiovascular, and cerebrovascular diseases. However, there is currently a paucity of relevant studies on the association between long-term level and change of TyG-index and cardiometabolic diseases (CMDs) risk. We aimed to explore the risk of CMDs in relation to the long-term level and change of TyG-index.

Methods: Based on the prospective cohort study, a total of 36359 subjects who were free of CMDs, had complete data of triglyceride (TG) and fasting blood glucose (FBG) and underwent four health check-ups from 2006 to 2012 consecutively were followed up for CMDs until 2021. The associations between long-term level and change of TyG-index and CMDs risk were assessed by Cox proportional hazards regression models to compute hazard ratios (HRs) and 95% confidence intervals (CIs). The TyG-index was calculated as ln [TG, mg/dL) × FBG, mg/dL)/2].

Results: During the median observation period of 8 years, 4685 subjects were newly diagnosed with CMDs. In multivariable-adjusted models, a graded positive association was observed between CMDs and long-term TyG-index. Compared with the Q1 group, subjects with the Q2-Q4 group had increased progressively risk of CMDs, with corresponding HRs of 1.64(1.47-1.83), 2.36(2.13-2.62), 3.15(2.84-3.49), respectively. The association was marginally attenuated, after further adjustment for the baseline TyG level. In addition, compared with stable TyG level, both loss and gain in TyG level were associated with increased CMDs risk.

Conclusions: Long-term elevated level and change of TyG-index are risk factors for the incident CMDs. Elevated TyG-index in the early stage remains to exert cumulative effects on the occurrence of CMDs even after accounting for the baseline TyG-index.

Keywords: cardiometabolic diseases; cohort study; cumulative effect; triglyceride-glucose index; triglyceride-glucose index change.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Flow chart of the current study.
Figure 2
Figure 2
HR of CMDs and TyG-index at baseline adjusted for all covariates (A) and additional adjustment for average TyG-index up to baseline (B).
Figure 3
Figure 3
HR of CMDs and TyG-index change adjusted for all covariates.
See this image and copyright information in PMC

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