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Review
. 2023 Jan-Dec:22:15330338231169873.
doi: 10.1177/15330338231169873.

A Review of Hedgehog Signaling in Radioresistant Esophageal Cancer: Potential Treatment Target

Li Ma  1 , Yu Wang  2 , Peng Chen  1 , Shixiu Wu  3
Affiliations
Review

A Review of Hedgehog Signaling in Radioresistant Esophageal Cancer: Potential Treatment Target

Li Ma et al. Technol Cancer Res Treat. 2023 Jan-Dec.

Abstract

Esophageal cancer is one of the most lethal malignancies worldwide. For locally advanced diseases, radiotherapy is the main treatment. The survival rates, however, are still appalling, which is partially due to radioresistance. In 6% of cases of esophageal cancer, the Hedgehog pathway is reactivated, and this pathway is crucial for the growth, progression, treatment resistance, and metastasis of esophageal cancer. Here, we conducted a comprehensive review of the current research on Hedgehog pathway in esophageal cancer.

Keywords: Hedgehog pathway; esophageal cancer; radioresistance; target therapy.

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Conflict of interest statement

The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
Hedgehog (HH) signaling pathway. The Hedgehog signaling pathway is inactive in the absence of sonic Hedgehog (SHH) ligand. In the presence of Shh, HH pathway can be activated. Ptch1-induced SMO repression is relieved, thereby allowing activation of SMO. This initiates Gli release from SUFU. Further promoting the increased Gli-target gene transcription.
Figure 2.
Figure 2.
Potential target therapy of hedgehog signaling pathway regulating radioresistance in esophageal cancer. Vismodegib, sonidegib, glasdegib, and Taladegib suppress HH pathway by repressing the function of SMO. Itraconazole reduces the release of Gli1 and further inhibits HH pathway.
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