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. 2023 Jun 1;30(7):e230028.
doi: 10.1530/ERC-23-0028. Print 2023 Jul 1.

Non-pituitary GH regulation of the tissue microenvironment

Vera Chesnokova  1 , Shlomo Melmed  1
Affiliations

Non-pituitary GH regulation of the tissue microenvironment

Vera Chesnokova et al. Endocr Relat Cancer. .

Abstract

Non-pituitary growth hormone (npGH) expression is well established in extrapituitary tissues, but an understanding of the physiological role of npGH remains rather limited. Pro-tumorigenic npGH impacting the tumor microenvironment has been reviewed. We focus here on autocrine/paracrine npGH effects in non-tumorous tissues and discuss its mechanisms of action in the normal tissue microenvironment. We address the tissue-specific effects of npGH in regulating stem, endothelial, immune, and epithelial cells and highlight the related role of npGH-associated changes in tissue aging.

Keywords: aging; non-pituitary growth hormone; non-tumorous tissue microenvironment.

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Conflict of interest statement

Declaration of Interests

The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research reported.

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