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Review
. 2023 Sep-Oct;89(5):700-709.
doi: 10.25259/IJDVL_298_2021.

Critical role of epigenetic modification in the pathogenesis of atopic dermatitis

Chunli Chen  1 , Jinrong Zeng  1 , Jianyun Lu  1
Affiliations
Free article
Review

Critical role of epigenetic modification in the pathogenesis of atopic dermatitis

Chunli Chen et al. Indian J Dermatol Venereol Leprol. 2023 Sep-Oct.
Free article

Abstract

Atopic dermatitis is a chronic inflammatory skin disease characterised by recurrent eczema-like lesions and severe pruritus, along with drying and decrustation of skin. Current research relates the pathogenesis of atopic dermatitis mainly to genetic susceptibility, abnormal skin barrier function, immune disorders, Staphylococcus aureus colonisation, microbiological dysfunction and vitamin D insufficiency. Epigenetic modifications are distinct genetic phenotypes resulting from environment-driven changes in chromosome functions in the absence of nuclear DNA sequence variation. Classic epigenetic events include DNA methylation, histone protein modifications and non-coding RNA regulation. Increasing evidence has indicated that epigenetic events are involved in the pathogenesis of atopic dermatitis by their effects on multiple signalling pathways which in turn influence the above factors. This review primarily analyses the function of epigenetic regulation in the pathogenesis of atopic dermatitis. In addition, it tries to make recommendations for personalised epigenetic treatment strategies for atopic dermatitis in the future.

Keywords: Atopic dermatitis; DNA methylation; histone modification; non-coding RNA; pathogenesis.

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References

    1. Weidinger S, Novak N,. Atopic dermatitis. Lancet. 2016; 387:1109-22
    1. Weidinger S, Beck LA, Bieber T, Kabashima K, Irvine AD,. Atopic dermatitis. Nat Rev Dis Primers. 2018; 4:1
    1. Jena PK, Sheng L, McNeil K, Chau TQ, Yu S, Kiuru M,et al. Long-term Western diet intake leads to dysregulated bile acid signaling and dermatitis with Th2 and Th17 pathway features in mice. J Dermatol Sci. 2019; 95:13-20
    1. Fotopoulou M, Iordanidou M, Vasileiou E, Trypsianis G, Chatzimichael A, Paraskakis E,. A short period of breastfeeding in infancy, excessive house cleaning, absence of older sibling, and passive smoking are related to more severe atopic dermatitis in children. Eur J Dermatol. 2018; 28:56-63
    1. Blakeway H, Van-de-Velde V, Allen VB, Kravvas G, Palla L, Page MJ,et al. What is the evidence for interactions between filaggrin null mutations and environmental exposures in the aetiology of atopic dermatitis? A systematic review. Br J Dermatol. 2020; 183:443-51

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