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. 2023 Oct;30(10):3077-3083.
doi: 10.1007/s43032-023-01237-5. Epub 2023 Apr 17.

Seminal Calbindin 2 in Infertile Men With Varicocele: A Prospective Comparative Study

Sameh Fayek GamalEl Din  1 , Ashraf Zeidan  2 , Mohamed Ahmed Abdel Salam  2 , Noha Abd El Hafeez Abd El Kader  3 , Sara Ahmed Mohamed  4 , Mohamed Farag Azmy  5
Affiliations

Seminal Calbindin 2 in Infertile Men With Varicocele: A Prospective Comparative Study

Sameh Fayek GamalEl Din et al. Reprod Sci. 2023 Oct.

Abstract

The present study compared seminal calbindin 2 (CALB 2) levels and semen parameters in men with and without varicocele. CALB 2 is also known as calretinin and 29 kDa calbindin. The study was a case-control study conducted from April (2021) to March (2022) in the andrology department at Beni-Suef University hospital. The study included four matched groups: group (I) were controls (fertile normozoospermic men without varicocele) (n=24). Group (II) were fertile normozoospermic men with varicocele (n=24). Group (III) were infertile oligoasthenoteratozoospermia (OAT) men without varicocele (n=24). Group (IV) were infertile OAT men with varicocele (n=24). The lowest levels of seminal CALB 2 were found in patients with severe oligozoospermia which showed a statistically significant difference when compared to seminal CALB 2 in patients with normal, mildly low, or moderately low sperm counts. There were significant negative correlations between sperm concentration, sperm motility and percentage of normal sperm forms and seminal CALB 2. Seminal plasma CALB 2 may play a role in the negative impact of varicocele on the semen parameters especially sperm concentration, sperm motility and percentage of sperm normal forms. Future studies are needed to verify these findings.

Keywords: Oligoasthenoteratozoospermia; Seminal plasma Calbindin 2 (Calretinin and 29 kDa Calbindin); Varicocele.

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Conflict of interest statement

All authors declare no conflict of interest.

Figures

Fig. 1
Fig. 1
Shows the correlation between seminal plasma CALB 2 and percentage of sperm normal forms
Fig. 2
Fig. 2
Shows the correlation between seminal plasma CALB 2 and sperm concentration
Fig. 3
Fig. 3
Shows the correlation between seminal plasma CALB 2 and sperm motility
See this image and copyright information in PMC

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