Claudin-18.2 targeting by zolbetuximab: results of SPOTLIGHT in perspective
- PMID: 37068506
- DOI: 10.1016/S0140-6736(23)00732-8
Claudin-18.2 targeting by zolbetuximab: results of SPOTLIGHT in perspective
Conflict of interest statement
HWMvL reports (all payments are made to their institution): a consultant or advisory role for AstraZeneca, Beigene, BMS, and MSD (all related to checkpoint inhibitors) and for Amphera, Daiichi-Sankyo, Dragonfly, Eli Lilly, Nordic Pharma, and Servier; research funding, medication supply, or both from Incyte, Merck, Roche, and Servier (all related to checkpoint inhibitors) and from Bayer, BMS, Celgene, Janssen, Eli Lilly, Nordic Pharma, and Philips; and speaker roles for Astellas (related to checkpoint inhibitors), Benecke, Daiichi-Sankyo, JAAP, Medtalks, Novartis, and Travel Congress Management. SD reports: a consultant or advisory role for BMS (related to checkpoint inhibitors); research funding, medication supply, or both from Incyte (related to checkpoint inhibitors); and speaker roles for Servier, BMS, and Benecke.
Comment on
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Zolbetuximab plus mFOLFOX6 in patients with CLDN18.2-positive, HER2-negative, untreated, locally advanced unresectable or metastatic gastric or gastro-oesophageal junction adenocarcinoma (SPOTLIGHT): a multicentre, randomised, double-blind, phase 3 trial.Lancet. 2023 May 20;401(10389):1655-1668. doi: 10.1016/S0140-6736(23)00620-7. Epub 2023 Apr 15. Lancet. 2023. PMID: 37068504 Clinical Trial.
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