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Review
. 2023 Jun:197:114823.
doi: 10.1016/j.addr.2023.114823. Epub 2023 Apr 15.

The applications of 3D printing in wound healing: The external delivery of stem cells and antibiosis

Qingtong Yu  1 , Qilong Wang  1 , Linzhi Zhang  1 , Wenwen Deng  1 , Xia Cao  1 , Zhe Wang  1 , Xuan Sun  1 , Jiangnan Yu  1 , Ximing Xu  2
Affiliations
Review

The applications of 3D printing in wound healing: The external delivery of stem cells and antibiosis

Qingtong Yu et al. Adv Drug Deliv Rev. 2023 Jun.

Abstract

As the global number of chronic wound patients rises, the financial burden and social pressure on patients increase daily. Stem cells have emerged as promising tissue engineering seed cells due to their enriched sources, multidirectional differentiation ability, and high proliferation rate. However, delivering them in vitro for the treatment of skin injury is still challenging. In addition, bacteria from the wound site and the environment can significantly impact wound healing. In the last decade, 3D bioprinting has dramatically enriched cell delivery systems. The produced scaffolds by this technique can be precisely localized within cells and perform antibacterial actions. In this review, we summarized the 3D bioprinting-based external delivery of stem cells and their antibiosis to improve wound healing.

Keywords: 3D bioprinting; Antibiosis; Biofilm; Skin regeneration; Stem cells; Wound healing.

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Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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