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Randomized Controlled Trial
. 2023 Apr 17;13(4):e070220.
doi: 10.1136/bmjopen-2022-070220.

Identifying women who may benefit from higher dose omega-3 supplementation during pregnancy to reduce their risk of prematurity: exploratory analyses from the ORIP trial

Lisa N Yelland  1   2 , Thomas R Sullivan  3   2 , Robert A Gibson  3   4 , Lucy A Simmonds  5 , Sagar K Thakkar  6 , Fang Huang  7 , Surabhi Devaraj  8 , Karen P Best  3   9 , Irma Silva Zolezzi  10 , Maria Makrides  3   9
Affiliations
Randomized Controlled Trial

Identifying women who may benefit from higher dose omega-3 supplementation during pregnancy to reduce their risk of prematurity: exploratory analyses from the ORIP trial

Lisa N Yelland et al. BMJ Open. .

Abstract

Objectives: The risk factors for prematurity are multifactorial and include low omega-3 status. Omega-3 supplementation in pregnancy has been found to reduce prematurity risk, particularly among women with low omega-3 levels. This study aimed to identify maternal characteristics that predict whether women with a singleton pregnancy will benefit from omega-3 supplementation to reduce their risk of prematurity.

Design: Exploratory analyses of a multicentre, double-blind randomised trial.

Setting: 6 tertiary care centres in four states in Australia.

Participants: 5328 singleton pregnancies in 5305 women recruited before 20 weeks of gestation.

Interventions: Fish oil capsules containing 900 mg omega-3 long-chain polyunsaturated fatty acids per day versus vegetable oil capsules consumed from enrolment until 34 weeks' gestation.

Outcome measures: Early preterm birth (EPTB, <34 weeks' gestation) and preterm birth (PTB, <37 weeks' gestation) analysed using logistic regression models with interactions between treatment group and a range of maternal biological, clinical and demographic characteristics.

Results: Omega-3 supplementation reduced the odds of EPTB for women with low total omega-3 status in early pregnancy (OR=0.30, 95% CI 0.10-0.93). No additional maternal characteristics influenced whether omega-3 supplementation reduced the odds of EPTB. For PTB, women were more likely to benefit from omega-3 supplementation if they were multiparous (OR=0.65, 95% CI 0.49-0.87) or avoided alcohol in the lead up to pregnancy (OR=0.62, 95% CI 0.45-0.86).

Conclusions: Our results support previous findings that women with low total omega-3 levels in early pregnancy are most likely to benefit from taking omega-3 supplements to reduce their risk of EPTB. Understanding how other maternal characteristics influence the effectiveness of omega-3 supplementation on reducing PTB requires further investigation.

Trial registration number: ACTRN12613001142729.

Keywords: NEONATOLOGY; NUTRITION & DIETETICS; OBSTETRICS; PUBLIC HEALTH.

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Conflict of interest statement

Competing interests: RAG has received supplies from Croda UK, prepared supplies for a trial for Efamol/Wassen UK and holds a patent (WO2013/104025A1) on stabilising and analysing fatty acids in a biological sample stored on solid media, owned by Adelaide Research and Innovation, The University of Adelaide, and licensed to Xerion. SKT, FH, SD and ISZ are employees of Société des Produits Nestlé (SPN). MM has received supplies from Croda UK and prepared supplies for a trial for Efamol/Wassen UK.

Figures

Figure 1
Figure 1
Flow chart of participants in the Omega-3 to Reduce the Incidence of Prematurity (ORIP) trial and the data available for this exploratory analysis.
See this image and copyright information in PMC

References

    1. United Nations Inter-agency Group for Child Mortality Estimation . Levels & trends in child mortality: report 2017, estimates developed by the UN inter-agency group for child mortality estimation. 2017. - PMC - PubMed
    1. Middleton P, Gomersall JC, Gould JF, et al. . Omega-3 fatty acid addition during pregnancy. Cochrane Database Syst Rev 2018;11:CD003402. 10.1002/14651858.CD003402.pub3 - DOI - PMC - PubMed
    1. Zhou SJ, Best K, Gibson R, et al. . Study protocol for a randomised controlled trial evaluating the effect of prenatal omega-3 LCPUFA supplementation to reduce the incidence of preterm birth: the oriP trial. BMJ Open 2017;7:e018360. 10.1136/bmjopen-2017-018360 - DOI - PMC - PubMed
    1. Makrides M, Best K, Yelland L, et al. . A randomized trial of prenatal n-3 fatty acid supplementation and preterm delivery. N Engl J Med 2019;381:1035–45. 10.1056/NEJMoa1816832 - DOI - PubMed
    1. Simmonds LA, Sullivan TR, Skubisz M, et al. . Omega-3 fatty acid supplementation in pregnancy-baseline omega-3 status and early preterm birth: exploratory analysis of a randomised controlled trial. BJOG 2020;127:975–81. 10.1111/1471-0528.16168 - DOI - PubMed

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