Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Aug;130(9):1047-1058.
doi: 10.1111/1471-0528.17460. Epub 2023 Apr 17.

Chorionicity and neurodevelopmental outcomes at 5½ years among twins born preterm: the EPIPAGE2 cohort study

Delphine Hoarau  1 , Barthélémy Tosello  1   2 , Julie Blanc  3   4 , Elsa Lorthe  5   6 , Laurence Foix-L'Helias  5   7 , Claude D'Ercole  3 , Norbert Winer  8 , Damien Subtil  9 , François Goffinet  5   10 , Gilles Kayem  5   10 , Noémie Resseguier  4 , Catherine Gire  1 ; EPIPAGE2 Obstetric Writing Group*
Collaborators, Affiliations

Chorionicity and neurodevelopmental outcomes at 5½ years among twins born preterm: the EPIPAGE2 cohort study

Delphine Hoarau et al. BJOG. 2023 Aug.

Abstract

Objective: To compare the neurodevelopmental outcomes of preterm twins at 5½ years by chorionicity of pregnancy.

Design: Prospective nationwide population-based EPIPAGE2 (Etude Epidémiologique sur les Petits Âges Gestationnels) cohort study.

Setting: A total of 546 maternity units in France, between March and December 2011.

Population: A total of 1126 twins eligible for follow-up at 5½ years.

Methods: The association of chorionicity with outcomes was analysed using multivariate regression models.

Main outcome measures: Survival at 5½ years with or without neurodevelopmental disabilities (comprising cerebral palsy, visual, hearing, cognitive deficiency, behavioural difficulties or developmental coordination disorders) were described and compared by chorionicity.

Results: Among the 1126 twins eligible for follow-up at 5½ years, 926 (82.2%) could be evaluated: 228 monochorionic (MC) and 698 dichorionic (DC). Based on chronicity and gestational age of birth, we found no significant differences for severe neonatal morbidity. The rates of moderate/severe neurobehavioral disabilities were similar in infants from DC pregnancies versus infants from MC pregnancies (OR 1.22, 95% CI 0.65-2.28). By gestational age and without twin-twin transfusion syndrome (TTTS), no difference according to chorionicity was found for all neurodevelopmental outcome measures.

Conclusions: The neurodevelopmental outcomes among preterm twins at 5½ years is similar, irrespective of chorionicity.

Keywords: 5-year outcomes; chorionicity; disability; monochorionic pregnancies; morbidity; neurodevelopment; preterm birth; twins.

PubMed Disclaimer

References

REFERENCES

    1. Blondel B , Durox M , Zeitlin J . How perinatal health in France compared with other European countries in 2015: some progress but also some concerns about newborn health. J Gynecol Obstet Hum Reprod. 2019;48(7):437-9.
    1. Blondel B . Increase in twin maternities and consequences on health. J Gynecol Obstet Biol Reprod. 2009;38(8 Suppl):S7-17.
    1. Chauhan S , Scardo J , Hayes E , Abuhamad AZ , Berghella V . Twins: prevalence, problems, and preterm births. Am J Obstet Gynecol. 2010;203:305-15.
    1. Ananth CV , Chauhan SP . Epidemiology of twinning in developed countries. Semin Perinatol. 2012;36(3):156-61.
    1. Hack KEA , Derks JB , Elias SG , Franx A , Roos EJ , Voerman SK , et al. Increased perinatal mortality and morbidity in monochorionic versus dichorionic twin pregnancies: clinical implications of a large Dutch cohort study. BJOG. 2008;115(1):58-67.

LinkOut - more resources