Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Apr 15;12(4):bio059847.
doi: 10.1242/bio.059847. Epub 2023 Apr 18.

New horizons of microphysiological systems: India forging its path in human-relevant research

Surat Parvatam  1 , Kasturi Mahadik  1 , Anushka Banerjee  1 , Kadambari Patil  1 , V Radha  2 , Madhusudhana Rao  1
Affiliations

New horizons of microphysiological systems: India forging its path in human-relevant research

Surat Parvatam et al. Biol Open. .

Abstract

The past decade has seen expeditious developments in our ability to grow and maintain a variety of human cells and tissues, with properties closely mimicking those in the human body. Prominent researchers and entrepreneurs from all over the world assembled in Hyderabad, India to discuss developments in this field that have not only aided fundamental understanding of organ development and disease processes but have served as good physiological models for toxicity testing and drug development. The speakers presented ingenious, cutting-edge technology and forward-thinking ideas. This report presents the salient aspects of their discussions, highlights the importance of identifying unmet needs, and discusses setting of standards that will help regulatory approvals as we move into a new era, with nominal animal use in research and effective drug discovery.

Keywords: Microphysiological systems; Organ-on-chip; Organoid; Stem cell biology.

PubMed Disclaimer

Conflict of interest statement

Competing interests The authors declare no competing or financial interests.

Figures

Fig. 1.
Fig. 1.
Participants of the India | EMBO lecture course held at Hyderabad, India from Oct 31-Nov 4, 2022.
Fig. 2.
Fig. 2.
Speaker (n=26) and participant (n=99) distributions at the India | EMBO: MPS lecture course.
Fig. 3.
Fig. 3.
Microfabrication and setting-up of MPS models during the hands-on session.
Fig. 4.
Fig. 4.
Feedback on the India | EMBO MPS lecture course from 75 attendees (68 participants and seven speakers).
See this image and copyright information in PMC

References

    1. Acharekar, A., Bachal, K., Shirke, P., Thorat, R., Banerjee, A., Gardi, N., Majumder, A. and Dutt, S. (2023). Substrate stiffness regulates the recurrent glioblastoma cell morphology and aggressiveness. Matrix Biol. 115, 107-127. 10.1016/j.matbio.2022.12.002 - DOI - PubMed
    1. Dahl-Jensen, S. and Grapin-Botton, A. (2017). The physics of organoids: a biophysical approach to understanding organogenesis. Development 144, 946-951. 10.1242/dev.143693 - DOI - PubMed
    1. Dasari, V., Bolimera, P. R., Dokku, S. K., Gorti, L. K. and Dravida, S. (2022). Neurotoxins induced toxicogenomic patterns on human induced pluripotent stem cell based microphysiological system. Med. Res. Arch. 10, 1-23. 10.18103/mra.v10i10.3202 - DOI
    1. Eichmüller, O. L. and Knoblich, J. A. (2022). Human cerebral organoids — a new tool for clinical neurology research. Nat. Rev. Neurol. 18, 661-680. 10.1038/s41582-022-00723-9 - DOI - PMC - PubMed
    1. Gayan, S., Teli, A., Nair, A., Tomar, G. and Dey, T. (2022). Macro- and micro-nutrient–based multiplex stress conditions modulate in vitro tumorigenesis and aggressive behavior of breast cancer spheroids. In Vitro Models 1, 85-101. 10.1007/s44164-021-00006-5 - DOI

Publication types