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. 2023 Aug;280(8):3867-3875.
doi: 10.1007/s00405-023-07971-5. Epub 2023 Apr 18.

A nomogram for predicting overall survival of patients with squamous cell carcinoma of the floor of the mouth: a population-based study

Yuxiao Cao #  1   2 , Wenyi Liu #  3   4   5 , Dantong Gu  6
Affiliations

A nomogram for predicting overall survival of patients with squamous cell carcinoma of the floor of the mouth: a population-based study

Yuxiao Cao et al. Eur Arch Otorhinolaryngol. 2023 Aug.

Abstract

Background: Floor of mouth squamous cell carcinoma (SCCFOM) is a rare but aggressive malignancy with 5-year overall survival (OS) rates below 40% in published studies. However, the clinicopathological predictors of the prognosis of SCCFOM remain undefined. We aimed to establish a model to predict the survival outcomes of SCCFOM.

Methods: We searched the Surveillance, Epidemiology, and End Results (SEER) database for patients diagnosed with SCCFOM between 2000 and 2017. Data on patient demographics, treatment modalities, and survival outcomes were retrieved. Risk factors for OS were evaluated by survival and Cox regression analyses. A nomogram for OS was developed based on the multivariate model and split the patients into high- and low-risk cohorts based on cutoff values.

Results: Overall, 2014 SCCFOM patients were included in this population-based study. Multivariate Cox regression showed that age, married status, grade, American Joint Committee on Cancer stage, radiotherapy, chemotherapy, and surgery were significant risk factors for survival. A nomogram was established using the regression model. The C-indices, areas under the receiver operating characteristic curves, and calibration plots demonstrated the reliable performance of the nomogram. Patients assigned to the high-risk group had a significantly lower survival rate.

Conclusions: The nomogram predicting survival outcomes of SCCFOM patients based on clinical information showed good discriminative ability and prognostic accuracy. Our nomogram could be used to predict the survival probabilities for SCCFOM patients at different timepoints.

Keywords: Nomogram; Overall survival; SEER database; Squamous cell carcinoma of the floor of the mouth.

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References

    1. Siegel RL et al (2022) Cancer statistics, 2022. CA Cancer J Clin 72(1):7–33 - DOI - PubMed
    1. Shield KD et al (2017) The global incidence of lip, oral cavity, and pharyngeal cancers by subsite in 2012. CA Cancer J Clin 67(1):51–64 - DOI - PubMed
    1. Zhang Y et al (2015) Different levels in alcohol and tobacco consumption in head and neck cancer patients from 1957 to 2013. PLoS ONE 10(4):e0124045 - DOI - PubMed - PMC
    1. Winn DM et al (2015) The INHANCE consortium: toward a better understanding of the causes and mechanisms of head and neck cancer. Oral Dis 21(6):685–693 - DOI - PubMed
    1. Saggi S et al (2018) Clinicopathologic characteristics and survival outcomes in floor of mouth squamous cell carcinoma: a population-based study. Otolaryngol Head Neck Surg 159(1):51–58 - DOI - PubMed

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