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. 1986 Apr;29(4):710-2.
doi: 10.1128/AAC.29.4.710.

Aztreonam penetration into synovial fluid and bone

C M MacLeod, E A Bartley, J O Galante, L T Friedhoff, R Dhruv

Aztreonam penetration into synovial fluid and bone

C M MacLeod et al. Antimicrob Agents Chemother. 1986 Apr.

Abstract

Eighteen patients with uncomplicated degenerative joint disease requiring joint replacement (hip or knee) were given a single 2-g intravenous dose of aztreonam over a 5-min period preoperatively. The mean concentration in synovial fluid of 83.0 +/- 9.2 micrograms/ml averaged 0.99 times the concomitant levels in serum. The mean concentration in cancellous bone of 16.0 +/- 4.3 micrograms/g averaged 0.20 times the concomitant levels in serum.

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