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. 2023 Jun 1;18(6):777-784.
doi: 10.2215/CJN.0000000000000176. Epub 2023 Apr 18.

Kidney Stone Events after Kidney Transplant in the United States

Calyani Ganesan  1 , Malorie Holmes  1 , Sai Liu  1 , Maria Montez-Rath  1 , Simon Conti  2 , Timothy C Chang  2   3 , Colin R Lenihan  1 , Xingxing S Cheng  1 , Glenn M Chertow  1 , John T Leppert  1   2   3 , Alan C Pao  1   2   3
Affiliations

Kidney Stone Events after Kidney Transplant in the United States

Calyani Ganesan et al. Clin J Am Soc Nephrol. .

Abstract

Background: Kidney stone disease is common and can lead to complications such as AKI, urinary tract obstruction, and urosepsis. In kidney transplant recipients, complications from kidney stone events can also lead to rejection and allograft failure. There is limited information on the incidence of kidney stone events in transplant recipients.

Methods: We identified 83,535 patients from the United States Renal Data System who received their first kidney transplant between January 1, 2007, and December 31, 2018. We examined the incidence of kidney stone events and identified risk factors associated with a kidney stone event in the first 3 years after transplantation.

Results: We found 1436 patients (1.7%) who were diagnosed with a kidney stone in the 3 years after kidney transplant. The unadjusted incidence rate for a kidney stone event was 7.8 per 1000 person-years. The median time from transplant to a kidney stone diagnosis was 0.61 (25%-75% range 0.19-1.46) years. Patients with a history of kidney stones were at greatest risk of a kidney stone event after transplant (hazard ratio [HR], 4.65; 95% confidence interval [CI], 3.82 to 5.65). Other notable risk factors included a diagnosis of gout (HR, 1.53; 95% CI, 1.31 to 1.80), hypertension (HR, 1.29; 95% CI, 1.00 to 1.66), and a dialysis of vintage of ≥9 years (HR, 1.48; 95% CI, 1.18 to 1.86; ref vintage ≤2.5 years).

Conclusions: Approximately 2% of kidney transplant recipients were diagnosed with a kidney stone in the 3 years after kidney transplant. Risk factors of a kidney stone event include a history of kidney stones and longer dialysis vintage.

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Figures

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Graphical abstract
Figure 1
Figure 1
Cohort diagram.
Figure 2
Figure 2
Cumulative incidence of kidney stone or death or graft failure in first-time kidney transplant patients.
See this image and copyright information in PMC

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