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Review
. 2023 Sep;20(9):560-574.
doi: 10.1038/s41585-023-00761-y. Epub 2023 Apr 18.

The androgen receptor in bladder cancer

Jinbo Chen #  1   2   3 , Chi-Ping Huang #  4 , Chao Quan  1 , Xiongbing Zu  5   6 , Zhenyu Ou  1   2   3 , Yu-Chieh Tsai  3 , Edward Messing  3 , Shuyuan Yeh  3 , Chawnshang Chang  7   8
Affiliations
Review

The androgen receptor in bladder cancer

Jinbo Chen et al. Nat Rev Urol. 2023 Sep.

Abstract

Bladder cancer is the ninth most common cancer worldwide with a striking sex-based difference in incidence. Emerging evidence indicates that the androgen receptor (AR) might promote the development, progression and recurrence of bladder cancer, contributing to the observed sex differences. Targeting androgen-AR signalling has promise as potential therapy for bladder cancer and helps to suppress progression of this disease. In addition, the identification of a new membrane AR and AR-regulated non-coding RNAs has important implications for bladder cancer treatment. The success of human clinical trials of targeted-AR therapies will help in the development of improved treatments for patients with bladder cancer.

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