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Review
. 2023 Aug;46(4):1144-1160.
doi: 10.1007/s10753-023-01808-3. Epub 2023 Apr 18.

Transient Receptor Potential Canonical 6 (TRPC6) Channel in the Pathogenesis of Diseases: A Jack of Many Trades

Uzma Saqib  1 , Sreepadaarchana Munjuluri  2 , Sutripta Sarkar  3 , Subir Biswas  4 , Oyshi Mukherjee  3 , Hargopal Satsangi  5 , Mirza S Baig  6 , Alexander G Obukhov  7   8 , Krishnan Hajela  9
Affiliations
Review

Transient Receptor Potential Canonical 6 (TRPC6) Channel in the Pathogenesis of Diseases: A Jack of Many Trades

Uzma Saqib et al. Inflammation. 2023 Aug.

Abstract

The mammalian Transient Receptor Potential Canonical (TRPC) subfamily comprises seven transmembrane proteins (TRPC1-7) forming cation channels in the plasma membrane of mammalian cells. TRPC channels mediate Ca2+ and Na+ influx into the cells. Amongst TRPCs, TRPC6 deficiency or increased activity due to gain-of-function mutations has been associated with a multitude of diseases, such as kidney disease, pulmonary disease, and neurological disease. Indeed, the TRPC6 protein is expressed in various organs and is involved in diverse signalling pathways. The last decade saw a surge in the investigative studies concerning the physiological roles of TRPC6 and describing the development of new pharmacological tools modulating TRPC6 activity. The current review summarizes the progress achieved in those investigations.

Keywords: Fibrosis; Inflammation; Ion channels; Signalling; TRPC6.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Involvement of TRPC6 signalling in various diseases and pathological conditions. The structure of TRPC6 protein was redrawn from PDB:7dxf.
Fig. 2
Fig. 2
The diagram summarizes the roles of TRPC6 in the pathogenesis of kidney diseases [–36].
Fig. 3
Fig. 3
The diagram summarizes the roles of TRPC6 in the nervous system [–52].
Fig. 4
Fig. 4
The diagram summarizes the roles of TRPC6 in the pathogenesis of cardiovascular diseases [–93].
Fig. 5
Fig. 5
The diagram summarizes the roles of TRPC6 in the pathogenesis of pulmonary diseases [–111].
See this image and copyright information in PMC

References

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