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Review
. 2023 Apr 18;22(1):89.
doi: 10.1186/s12933-023-01827-2.

L-Arginine in diabetes: clinical and preclinical evidence

Imma Forzano #  1 , Roberta Avvisato #  1 , Fahimeh Varzideh  1 , Stanislovas S Jankauskas  1 , Angelo Cioppa  1   2 , Pasquale Mone  1 , Luigi Salemme  2 , Urna Kansakar  1 , Tullio Tesorio  2 , Valentina Trimarco  1   3 , Gaetano Santulli  4   5
Affiliations
Review

L-Arginine in diabetes: clinical and preclinical evidence

Imma Forzano et al. Cardiovasc Diabetol. .

Erratum in

  • Correction: L-Arginine in diabetes: clinical and preclinical evidence.
    Forzano I, Avvisato R, Varzideh F, Jankauskas SS, Cioppa A, Mone P, Salemme L, Kansakar U, Tesorio T, Trimarco V, Santulli G. Forzano I, et al. Cardiovasc Diabetol. 2023 May 18;22(1):117. doi: 10.1186/s12933-023-01852-1. Cardiovasc Diabetol. 2023. PMID: 37208744 Free PMC article. No abstract available.

Abstract

L-Arginine (L-Arg), is a semi-essential amino acid involved in the formation of nitric oxide. The functional relevance of L-Arg in diabetes mellitus has been evaluated both in animal models and in human subjects. In the literature there are several lines of evidence indicating that L-Arg has beneficial effects in diabetes and numerous studies advocate its administration to attenuate glucose intolerance in diabetic patients. Here we present a comprehensive overview of the main studies exploring the effects of L-Arg in diabetes, including preclinical and clinical reports on this topic.

Keywords: Diabetes mellitus; Endothelial dysfunction; GLP-1; Glucose metabolism; L-Arginine; NO.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
L-Arg once in the cell can be metabolized by Arginase. The products of this enzyme are: L-Ornithine, which is further cleaved to polyamines by ornithine decarboxylase (ODC), L-proline by ornithine aminotransferase (OAT), and urea. These compounds exert negative effects on glucose metabolism. When L-Arg is cleaved in nitric oxide (NO) and L-citrulline by the nitric oxide synthase (NOS), these compounds have positive effects on glucose metabolism, also exerting beneficial action on the cardiovascular system
See this image and copyright information in PMC

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