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Multicenter Study
. 2023 Jun;102(6):1433-1442.
doi: 10.1007/s00277-023-05232-3. Epub 2023 Apr 19.

The prognostic value of controlling nutritional status (CONUT) score-based nomogram on extranodal natural killer/T cell lymphoma patients

Shuo Zhang #  1 , Cai Sun #  1 , Xicheng Chen #  1 , Dashan Li  1 , Lingling Hu  1 , Meng Zhang  1 , Xudong Zhang  2 , Hao Zhang  3 , Jingjing Ye  4 , Ling Wang  5 , Tao Jia  6 , Taigang Zhu  7 , Yuqing Miao  8 , Chunling Wang  9 , Liang Wang  10 , Dongmei Yan  1 , Ziyuan Shen  11 , Wei Sang  12
Affiliations
Multicenter Study

The prognostic value of controlling nutritional status (CONUT) score-based nomogram on extranodal natural killer/T cell lymphoma patients

Shuo Zhang et al. Ann Hematol. 2023 Jun.

Abstract

Controlling nutritional status (CONUT) score as an original nutritional assessment tool can be used to assess the prognosis of patients with a variety of malignancies. However, the predictive power of CONUT in extranodal natural killer/T cell lymphoma (ENKTL) patients has never been demonstrated. Our retrospective multicenter study aimed to explore the prognostic value of CONUT in newly diagnosed ENKTL. A total of 1085 newly diagnosed ENKTL patients between 2003 and 2021 were retrospectively retrieved. Cox proportional hazard model was used to explore the prognostic factors of overall survival (OS). The survival rate of ENKTL was evaluated using Kaplan-Meier analysis, and log-rank test was applied to the difference between groups. We investigated the prognostic performance of CONUT, the International Prognostic Index (IPI), the Korean Prognostic Index (KPI), and the Prognostic Index of Natural Killer Cell Lymphoma (PINK) using the receiver operating characteristic (ROC) curve and decision curve analysis (DCA). The median age at diagnosis for the whole cohort was 47 years, and the male to female ratio was 2.2:1. The 5-year OS for all patients was 72.2%. Multivariable analysis showed that CONUT, age, bone marrow involvement, ECOG PS score, and Chinese Southwest Oncology Group and Asia Lymphoma Study Group ENKTL stage were identified as independent predictive factors for OS. Based on multivariable results, a prognostic nomogram was developed. Subgroup analysis demonstrated that patients with severe malnutrition had poorest clinical outcome. In addition, ROC curves and DCA analysis proved that compared with IPI, KPI, and PINK models, the CONUT score-based nomogram showed a better prognostic predictive efficiency of ENKTL. CONUT could effectively stratify the prognosis of ENKTL and the proposed nomogram based on CONUT was an effective prognostic model for prediction.

Keywords: Controlling Nutritional Status score; Extranodal natural killer/T cell lymphoma; Nomogram; Nutritional indices; Prognosis.

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References

    1. Tse E, Kwong YL (2017) The diagnosis and management of NK/T-cell lymphomas. J Hematol Oncol 10:85. https://doi.org/10.1186/s13045-017-0452-9 - DOI - PubMed - PMC
    1. Missaoui N, Mestiri S, Bouriga A, Abdessayed N, Belakhdher M, Ghammem M et al (2019) Extranodal NK/T-cell lymphoma in Tunisia: clinicopathological features, immunophenotype and EBV infection. J Egypt Natl Canc Inst 31:1. https://doi.org/10.1186/s43046-019-0002-3 - DOI - PubMed
    1. Montes-Mojarro IA, Chen BJ, Ramirez-Ibarguen AF, Quezada-Fiallos CM, Perez-Baez WB, Duenas D et al (2020) Mutational profile and EBV strains of extranodal NK/T-cell lymphoma, nasal type in Latin America. Mod Pathol 33:781–791. https://doi.org/10.1038/s41379-019-0415-5 - DOI - PubMed
    1. Fox CP, Civallero M, Ko YH, Manni M, Skrypets T, Pileri S et al (2020) Survival outcomes of patients with extranodal natural-killer T-cell lymphoma: a prospective cohort study from the international T-cell Project. Lancet Haematol 7:e284–e294. https://doi.org/10.1016/s2352-3026(19)30283-2 - DOI - PubMed
    1. Li K, Wang R, Huang S, Pan X, Chen H, Zhou L et al (2018) Prognostic nomogram for overall survival in extranodal natural killer/T-cell lymphoma patients. Clin Lymphoma Myeloma Leuk 18:e537–e543. https://doi.org/10.1016/j.clml.2018.08.011 - DOI - PubMed

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