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Editorial
. 2023 Apr 25;81(16):1565-1568.
doi: 10.1016/j.jacc.2023.03.384.

Realizing the Potential of PCSK9 Inhibition: A Novel Oral Macrocyclic Peptide on the Horizon

M John Chapman  1 , Chris J Packard  2
Affiliations
Free article
Editorial

Realizing the Potential of PCSK9 Inhibition: A Novel Oral Macrocyclic Peptide on the Horizon

M John Chapman et al. J Am Coll Cardiol. .
Free article
No abstract available

Keywords: LDL cholesterol; PCSK9; atherosclerotic cardiovascular disease; lipoprotein(a); oral macrocyclic PCSK9 inhibitor; remnant lipoproteins; triglyceride-rich lipoproteins.

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Conflict of interest statement

Funding Support and Author Disclosures Prof Chapman has received honoraria from Amgen, Amarin, AstraZeneca, Daiichi-Sankyo, Kowa, Lexicon, MSD, Regeneron, Sanofi, and Pfizer. Prof Packard has received honoraria from Amgen, Amarin, MSD, Dalcor, Novartis, and Daiichi-Sankyo.

Comment on

  • Phase 2b Randomized Trial of the Oral PCSK9 Inhibitor MK-0616.
    Ballantyne CM, Banka P, Mendez G, Garcia R, Rosenstock J, Rodgers A, Mendizabal G, Mitchel Y, Catapano AL. Ballantyne CM, et al. J Am Coll Cardiol. 2023 Apr 25;81(16):1553-1564. doi: 10.1016/j.jacc.2023.02.018. Epub 2023 Mar 6. J Am Coll Cardiol. 2023. PMID: 36889610 Clinical Trial.

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