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. 2023 Apr;10(1):e001559.
doi: 10.1136/bmjresp-2022-001559.

Signs and symptoms of acute pulmonary embolism and their predictive value for all-cause hospital death in respect of severity of the disease, age, sex and body mass index: retrospective analysis of the Regional PE Registry (REPER)

Dušan Predrag Ružičić  1 , Boris Dzudovic  2   3 , Jovan Matijasevic  4   5 , Marija Benic  4 , Sonja Salinger  6   7 , Ljiljana Kos  8 , Tamara Kovacevic-Preradovic  8   9 , Irena Mitevska  10 , Aleksandar Neskovic  11   12 , Bjanka Bozovic  13 , Nebojsa Bulatovic  13   14 , Vladimir Miloradovic  15   16 , Ivica Djuric  17 , Slobodan Obradovic  18   17
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Signs and symptoms of acute pulmonary embolism and their predictive value for all-cause hospital death in respect of severity of the disease, age, sex and body mass index: retrospective analysis of the Regional PE Registry (REPER)

Dušan Predrag Ružičić et al. BMJ Open Respir Res. 2023 Apr.

Abstract

Background: The incidence of the signs and symptoms of acute pulmonary embolism (PE) according to mortality risk, age and sex has been partly explored.

Patients and methods: A total of 1242 patients diagnosed with acute PE and included in the Regional Pulmonary Embolism Registry were enrolled in the study. Patients were classified as low risk, intermediate risk or high risk according to the European Society of Cardiology mortality risk model. The incidence of the signs and symptoms of acute PE at presentation with respect to sex, age, and PE severity was investigated.

Results: The incidence of haemoptysis was higher in younger men with intermediate-risk (11.7% vs 7.5% vs 5.9% vs 2.3%; p=0.01) and high-risk PE (13.8% vs 2.5% vs 0.0% vs 3.1%; p=0.031) than in older men and women. The frequency of symptomatic deep vein thrombosis was not significantly different between subgroups. Older women with low-risk PE presented with chest pain less commonly (35.8% vs 55.8% vs 48.8% vs 51.9%, respectively; p=0.023) than men and younger women. However, younger women had a higher incidence of chest pain in the lower-risk PE group than in the intermediate-risk and high-risk PE subgroups (51.9%, 31.4% and 27.8%, respectively; p=0.001). The incidence of dyspnoea (except in older men), syncope and tachycardia increased with the risk of PE in all subgroups (p<0.01). In the low-risk PE group, syncope was present more often in older men and women than in younger patients (15.5% vs 11.3% vs 4.5% vs 4.5%; p=0.009). The incidence of pneumonia was higher in younger men with low-risk PE (31.8% vs<16% in the other subgroups, p<0.001).

Conclusion: Haemoptysis and pneumonia are prominent features of acute PE in younger men, whereas older patients more frequently have syncope with low-risk PE. Dyspnoea, syncope and tachycardia are symptoms of high-risk PE irrespective of sex and age.

Keywords: Pulmonary Embolism.

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Conflict of interest statement

Competing interests: The interpretation of the data and presentation of this investigation were not influenced by personal or financial relationships with other people or organisations.

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