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Randomized Controlled Trial
. 2023 Jun;79(6):841-848.
doi: 10.1007/s00228-023-03496-2. Epub 2023 Apr 19.

The role of time interval elimination on pain control of preterm infants by sucrose administration

Deniz Yaprak  1 , Belma Saygili Karagöl  2 , Ali Dinç Bozat  3 , İrem Kar  4
Affiliations
Randomized Controlled Trial

The role of time interval elimination on pain control of preterm infants by sucrose administration

Deniz Yaprak et al. Eur J Clin Pharmacol. 2023 Jun.

Abstract

Purpose: The 2-min time interval of sucrose administration given before minor painful procedures in preterm infants is based on a few limited studies. We aimed to assess availability of sucrose analgesia in emergency states of minor procedural pain by eliminating the 2-min time interval prior to heel lance in preterm infants. The primary outcome was Premature Infants Pain Profile-Revised (PIPP-R) at 30 and 60 s.

Methods: Healthy 69 preterms undergoing a heel lance, who were assigned randomly to 1 of 2 groups, i.e., group I, with the 2-min time interval of per oral 24% sucrose given prior to heel lance, or group II, without a time interval of per oral 24% sucrose, were recruited. Premature Infants Pain Profile-Revised, crying incidence, duration, and heart rate at 30 and 60 s following heel lance were the outcome measures in this single-center, randomized, prospective study.

Results: The 2 groups did not differ significantly in PIPP-R scores at 30 s (6.63 vs. 6.32, p = .578) and 60 s (5.80 vs. 5.38, p = .478). The crying incidence was similar between the 2 groups (p = .276). The median crying duration was 6 s (range: 1-13 s) in group I and 4.5 s (range: 1-18 s) in group II (p = .226). No significant differences in the heart rates between the 2 groups and the proportion of adverse events by time interval elimination were recorded.

Conclusions: Eliminating the time interval did not decrease the analgesic effect of orally administered 24% sucrose given prior to heel lance. In emergency states of minor procedural pain, eliminating the 2-min time interval following sucrose administration is safe and efficacious in preterm infants.

Keywords: PIPP-R scoring; Pain; Preterm; Sucrose.

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