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. 2024 Feb;479(2):351-362.
doi: 10.1007/s11010-023-04731-1. Epub 2023 Apr 19.

Curcumin can improve spinal cord injury by inhibiting DNA methylation

Yu Zhou #  1 , Yong Zhang #  1 , Benson O A Botchway #  2   3 , Xichen Wang  1 , Xuehong Liu  4
Affiliations

Curcumin can improve spinal cord injury by inhibiting DNA methylation

Yu Zhou et al. Mol Cell Biochem. 2024 Feb.

Abstract

Spinal cord injury (SCI) is a serious central nervous system disease. Traumatic SCI often causes persistent neurological deficits below the injury level. Epigenetic changes occur after SCI. Studies have shown DNA methylation to be a key player in nerve regeneration and remodeling, and in regulating some pathophysiological characteristics of SCI. Curcumin is a natural polyphenol from turmeric. It has anti-inflammatory, antioxidant, and neuroprotective effects, and can mitigate the cell and tissue damage caused by SCI. This report analyzed the specific functions of DNA methylation in central nervous system diseases, especially traumatic brain injury and SCI. DNA methylation can regulate the level of gene expressions in the central nervous system. Therefore, pharmacological interventions regulating DNA methylation may be promising for SCI.

Keywords: Curcumin; DNA methylation; Nuclear factor-κB; Pharmacological intervention; Spinal cord injury.

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