Biomarkers of aging

doi:10.1007/s11427-023-2305-0

Review

. 2023 May;66(5):893-1066.

doi: 10.1007/s11427-023-2305-0. Epub 2023 Apr 11.

Biomarkers of aging

Aging Biomarker Consortium; Hainan Bao^#¹, Jiani Cao^#², Mengting Chen^#^{3

4

5}, Min Chen^#^{6

7

8}, Wei Chen^#⁹, Xiao Chen^#¹⁰, Yanhao Chen^#¹¹, Yu Chen^#¹², Yutian Chen^#¹³, Zhiyang Chen^#¹⁴, Jagadish K Chhetri^#¹⁵, Yingjie Ding^#^{1

16}, Junlin Feng^#¹⁷, Jun Guo^#¹⁸, Mengmeng Guo^#¹⁹, Chuting He^#^{16

20

21

22}, Yujuan Jia^#²³, Haiping Jiang^#^{2

16

21

22}, Ying Jing^#^{24

25

26}, Dingfeng Li^#²⁷, Jiaming Li^#^{1

16}, Jingyi Li^#^{16

20

21

22}, Qinhao Liang^#²⁸, Rui Liang^#²⁹, Feng Liu^#³⁰, Xiaoqian Liu^#^{2

16

21

22}, Zuojun Liu^#³¹, Oscar Junhong Luo^#³², Jianwei Lv^#³³, Jingyi Ma^#³⁴, Kehang Mao^#³⁵, Jiawei Nie^#³⁶, Xinhua Qiao^#³⁷, Xinpei Sun^#³⁸, Xiaoqiang Tang^#³⁹, Jianfang Wang^#⁴⁰, Qiaoran Wang^#^{1

16}, Siyuan Wang^#⁴¹, Xuan Wang^#⁴², Yaning Wang^#^{43

44}, Yuhan Wang^#^{16

20

21

22}, Rimo Wu^#⁴⁵, Kai Xia^#^{46

47}, Fu-Hui Xiao^#^{48

49}, Lingyan Xu^#⁵⁰, Yingying Xu^#¹, Haoteng Yan^#^{24

25

26}, Liang Yang^#⁵¹, Ruici Yang^#⁵², Yuanxin Yang^#⁵³, Yilin Ying^#^{54

55}, Le Zhang^#^{56

57}, Weiwei Zhang^#⁵⁸, Wenwan Zhang^#¹⁷, Xing Zhang^#⁵⁹, Zhuo Zhang^#^{60

61}, Min Zhou^#⁶², Rui Zhou^#⁶³, Qingchen Zhu^#¹⁷, Zhengmao Zhu^#^{64

65}, Feng Cao⁶⁶, Zhongwei Cao⁶⁷, Piu Chan⁶⁸, Chang Chen⁶⁹, Guobing Chen^{70

71}, Hou-Zao Chen⁷², Jun Chen⁷³, Weimin Ci⁷⁴, Bi-Sen Ding⁷⁵, Qiurong Ding⁷⁶, Feng Gao⁷⁷, Jing-Dong J Han⁷⁸, Kai Huang^{79

80

81

82}, Zhenyu Ju⁸³, Qing-Peng Kong^{84

85}, Ji Li^{86

87

88}, Jian Li⁸⁹, Xin Li^{90

91

92

93}, Baohua Liu⁹⁴, Feng Liu⁹⁵, Lin Liu^{96

97

98

99}, Qiang Liu¹⁰⁰, Qiang Liu^{101

102}, Xingguo Liu¹⁰³, Yong Liu¹⁰⁴, Xianghang Luo¹⁰⁵, Shuai Ma^{106

107

108

109}, Xinran Ma¹¹⁰, Zhiyong Mao¹¹¹, Jing Nie¹¹², Yaojin Peng^{113

114

115}, Jing Qu^{116

117

118

119}, Jie Ren^{120

121

122}, Ruibao Ren^{123

124}, Moshi Song^{125

126

127

128}, Zhou Songyang^{129

130}, Yi Eve Sun¹³¹, Yu Sun^{132

133}, Mei Tian¹³⁴, Shusen Wang¹³⁵, Si Wang^{136

137

138}, Xia Wang¹³⁹, Xiaoning Wang¹⁴⁰, Yan-Jiang Wang¹⁴¹, Yunfang Wang¹⁴², Catherine C L Wong¹⁴³, Andy Peng Xiang^{144

145}, Yichuan Xiao¹⁴⁶, Zhengwei Xie^{147

148}, Daichao Xu¹⁴⁹, Jing Ye^{150

151}, Rui Yue¹⁵², Cuntai Zhang^{153

154}, Hongbo Zhang^{155

156}, Liang Zhang^{157

158}, Weiqi Zhang^{159

160

161}, Yong Zhang^{162

163}, Yun-Wu Zhang¹⁶⁴, Zhuohua Zhang^{165

166}, Tongbiao Zhao^{167

168

169

170}, Yuzheng Zhao^{171

172}, Dahai Zhu^{173

174}, Weiguo Zou¹⁷⁵, Gang Pei¹⁷⁶, Guang-Hui Liu^{177

178

179

180

181}

Affiliations

¹ CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing, 100101, China.
² State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.
³ Department of Dermatology, Xiangya Hospital, Central South University, Changsha, 410008, China.
⁴ Hunan Key Laboratory of Aging Biology, Xiangya Hospital, Central South University, Changsha, 410008, China.
⁵ National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, 410008, China.
⁶ Clinic Center of Human Gene Research, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
⁷ Hubei Clinical Research Center of Metabolic and Cardiovascular Disease, Huazhong University of Science and Technology, Wuhan, 430022, China.
⁸ Hubei Key Laboratory of Metabolic Abnormalities and Vascular Aging, Huazhong University of Science and Technology, Wuhan, 430022, China.
⁹ Stem Cell Translational Research Center, Tongji Hospital, Tongji University School of Medicine, Shanghai, 200065, China.
¹⁰ Department of Nuclear Medicine, Daping Hospital, Third Military Medical University, Chongqing, 400042, China.
¹¹ CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China.
¹² Shanghai Key Laboratory of Maternal Fetal Medicine, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Frontier Science Center for Stem Cell Research, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, China.
¹³ The Department of Endovascular Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
¹⁴ Key Laboratory of Regenerative Medicine of Ministry of Education, Institute of Ageing and Regenerative Medicine, Jinan University, Guangzhou, 510632, China.
¹⁵ National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China.
¹⁶ University of Chinese Academy of Sciences, Beijing, 100049, China.
¹⁷ CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, Shanghai, 200031, China.
¹⁸ The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology of National Health Commission, Beijing, 100730, China.
¹⁹ School of Pharmaceutical Sciences, Tsinghua University, Beijing, 100084, China.
²⁰ State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.
²¹ Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China.
²² Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, 100101, China.
²³ Department of Neurology, First Affiliated Hospital, Shanxi Medical University, Taiyuan, 030001, China.
²⁴ Beijing Municipal Geriatric Medical Research Center, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China.
²⁵ Aging Translational Medicine Center, International Center for Aging and Cancer, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China.
²⁶ Advanced Innovation Center for Human Brain Protection, and National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing, 100053, China.
²⁷ Department of Neurology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230036, China.
²⁸ College of Life Sciences, TaiKang Center for Life and Medical Sciences, Wuhan University, Wuhan, 430072, China.
²⁹ Research Institute of Transplant Medicine, Organ Transplant Center, NHC Key Laboratory for Critical Care Medicine, Tianjin First Central Hospital, Nankai University, Tianjin, 300384, China.
³⁰ MOE Key Laboratory of Gene Function and Regulation, Guangzhou Key Laboratory of Healthy Aging Research, School of Life Sciences, Institute of Healthy Aging Research, Sun Yat-sen University, Guangzhou, 510275, China.
³¹ School of Life Sciences, Hainan University, Haikou, 570228, China.
³² Department of Systems Biomedical Sciences, School of Medicine, Jinan University, Guangzhou, 510632, China.
³³ School of Life Sciences, Xiamen University, Xiamen, 361102, China.
³⁴ The State Key Laboratory of Organ Failure Research, National Clinical Research Center of Kidney Disease, Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
³⁵ Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Center for Quantitative Biology (CQB), Peking University, Beijing, 100871, China.
³⁶ Shanghai Institute of Hematology, State Key Laboratory for Medical Genomics, National Research Center for Translational Medicine (Shanghai), International Center for Aging and Cancer, Collaborative Innovation Center of Hematology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
³⁷ National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.
³⁸ Peking University International Cancer Institute, Health Science Center, Peking University, Beijing, 100101, China.
³⁹ Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, State Key Laboratory of Biotherapy, West China Second University Hospital, Sichuan University, Chengdu, 610041, China.
⁴⁰ Institute for Regenerative Medicine, Shanghai East Hospital, Frontier Science Center for Stem Cell Research, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, China.
⁴¹ Clinical Research Institute, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, 100730, China.
⁴² Hepatobiliary and Pancreatic Center, Medical Research Center, Beijing Tsinghua Changgung Hospital, Beijing, 102218, China.
⁴³ Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, China.
⁴⁴ Advanced Medical Technology Center, The First Affiliated Hospital, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, China.
⁴⁵ Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory), Guangzhou, 510005, China.
⁴⁶ Center for Stem Cell Biologyand Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-sen University, Guangzhou, 510080, China.
⁴⁷ National-Local Joint Engineering Research Center for Stem Cells and Regenerative Medicine, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, China.
⁴⁸ CAS Center for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences, Kunming, 650223, China.
⁴⁹ State Key Laboratory of Genetic Resources and Evolution, Key Laboratory of Healthy Aging Research of Yunnan Province, Kunming Key Laboratory of Healthy Aging Study, KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, China.
⁵⁰ Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, 200241, China.
⁵¹ CAS Key Laboratory of Regenerative Biology, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University, Guangzhou, 510530, China.
⁵² State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, 200031, China.
⁵³ Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, 201210, China.
⁵⁴ Department of Geriatrics, Medical Center on Aging of Shanghai Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
⁵⁵ International Laboratory in Hematology and Cancer, Shanghai Jiao Tong University School of Medicine/Ruijin Hospital, Shanghai, 200025, China.
⁵⁶ Gerontology Center of Hubei Province, Wuhan, 430000, China.
⁵⁷ Institute of Gerontology, Department of Geriatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
⁵⁸ Department of Cardiology, The Second Medical Centre, Chinese PLA General Hospital, National Clinical Research Center for Geriatric Diseases, Beijing, 100853, China.
⁵⁹ Key Laboratory of Ministry of Education, School of Aerospace Medicine, Fourth Military Medical University, Xi'an, 710032, China.
⁶⁰ Optogenetics & Synthetic Biology Interdisciplinary Research Center, State Key Laboratory of Bioreactor Engineering, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China.
⁶¹ Research Unit of New Techniques for Live-cell Metabolic Imaging, Chinese Academy of Medical Sciences, Beijing, 100730, China.
⁶² Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, 410008, China.
⁶³ Department of Nuclear Medicine and PET Center, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, 310009, China.
⁶⁴ Department of Genetics and Cell Biology, College of Life Science, Nankai University, Tianjin, 300071, China.
⁶⁵ Haihe Laboratory of Cell Ecosystem, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, 300020, China.
⁶⁶ Department of Cardiology, The Second Medical Centre, Chinese PLA General Hospital, National Clinical Research Center for Geriatric Diseases, Beijing, 100853, China. fengcao8828@163.com.
⁶⁷ State Key Laboratory of Biotherapy, West China Second University Hospital, Sichuan University, Chengdu, 610041, China. zhongweicao@scu.edu.cn.
⁶⁸ National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China. pbchan@hotmail.com.
⁶⁹ National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China. changchen@ibp.ac.cn.
⁷⁰ Department of Microbiology and Immunology, School of Medicine, Jinan University, Guangzhou, 510632, China. guobingchen@jnu.edu.cn.
⁷¹ Guangdong-Hong Kong-Macau Great Bay Area Geroscience Joint Laboratory, Guangzhou, 510000, China. guobingchen@jnu.edu.cn.
⁷² Department of Biochemistryand Molecular Biology, State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100005, China. chenhouzao@ibms.cams.cn.
⁷³ Peking University Research Center on Aging, Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, Department of Biochemistry and Molecular Biology, Department of Integration of Chinese and Western Medicine, School of Basic Medical Science, Peking University, Beijing, 100191, China. cjbiochem@bjmu.edu.cn.
⁷⁴ CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing, 100101, China. ciwm@big.ac.cn.
⁷⁵ State Key Laboratory of Biotherapy, West China Second University Hospital, Sichuan University, Chengdu, 610041, China. dingbisen@scu.edu.cn.
⁷⁶ CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China. qrding@sibs.ac.cn.
⁷⁷ Key Laboratory of Ministry of Education, School of Aerospace Medicine, Fourth Military Medical University, Xi'an, 710032, China. fgao@fmmu.edu.cn.
⁷⁸ Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Center for Quantitative Biology (CQB), Peking University, Beijing, 100871, China. jackie.han@pku.edu.cn.
⁷⁹ Clinic Center of Human Gene Research, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. huangkai1@hust.edu.cn.
⁸⁰ Hubei Clinical Research Center of Metabolic and Cardiovascular Disease, Huazhong University of Science and Technology, Wuhan, 430022, China. huangkai1@hust.edu.cn.
⁸¹ Hubei Key Laboratory of Metabolic Abnormalities and Vascular Aging, Huazhong University of Science and Technology, Wuhan, 430022, China. huangkai1@hust.edu.cn.
⁸² Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. huangkai1@hust.edu.cn.
⁸³ Key Laboratory of Regenerative Medicine of Ministry of Education, Institute of Ageing and Regenerative Medicine, Jinan University, Guangzhou, 510632, China. zhenyuju@163.com.
⁸⁴ CAS Center for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences, Kunming, 650223, China. kongqp@mail.kiz.ac.cn.
⁸⁵ State Key Laboratory of Genetic Resources and Evolution, Key Laboratory of Healthy Aging Research of Yunnan Province, Kunming Key Laboratory of Healthy Aging Study, KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, China. kongqp@mail.kiz.ac.cn.
⁸⁶ Department of Dermatology, Xiangya Hospital, Central South University, Changsha, 410008, China. liji_xy@csu.edu.cn.
⁸⁷ Hunan Key Laboratory of Aging Biology, Xiangya Hospital, Central South University, Changsha, 410008, China. liji_xy@csu.edu.cn.
⁸⁸ National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, 410008, China. liji_xy@csu.edu.cn.
⁸⁹ The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology of National Health Commission, Beijing, 100730, China. Lijian@bjhmoh.cn.
⁹⁰ State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China. xinli@ioz.ac.cn.
⁹¹ University of Chinese Academy of Sciences, Beijing, 100049, China. xinli@ioz.ac.cn.
⁹² Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China. xinli@ioz.ac.cn.
⁹³ Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, 100101, China. xinli@ioz.ac.cn.
⁹⁴ School of Basic Medical Sciences, Shenzhen University Medical School, Shenzhen, 518060, China. ppliew@szu.edu.cn.
⁹⁵ Metabolic Syndrome Research Center, The Second Xiangya Hospital, Central South Unversity, Changsha, 410011, China. liuf001@csu.edu.cn.
⁹⁶ Department of Genetics and Cell Biology, College of Life Science, Nankai University, Tianjin, 300071, China. liulin@nankai.edu.cn.
⁹⁷ Haihe Laboratory of Cell Ecosystem, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, 300020, China. liulin@nankai.edu.cn.
⁹⁸ Institute of Translational Medicine, Tianjin Union Medical Center, Nankai University, Tianjin, 300000, China. liulin@nankai.edu.cn.
⁹⁹ State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin, 300350, China. liulin@nankai.edu.cn.
¹⁰⁰ Department of Neurology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230036, China. liuq2012@ustc.edu.cn.
¹⁰¹ Department of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, 300052, China. qliu@tmu.edu.cn.
¹⁰² Tianjin Institute of Immunology, Tianjin Medical University, Tianjin, 300070, China. qliu@tmu.edu.cn.
¹⁰³ CAS Key Laboratory of Regenerative Biology, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University, Guangzhou, 510530, China. liu_xingguo@gibh.ac.cn.
¹⁰⁴ College of Life Sciences, TaiKang Center for Life and Medical Sciences, Wuhan University, Wuhan, 430072, China. liuyong31279@whu.edu.cn.
¹⁰⁵ Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, 410008, China. xianghangluo@csu.edu.cn.
¹⁰⁶ University of Chinese Academy of Sciences, Beijing, 100049, China. mashuai@ioz.ac.cn.
¹⁰⁷ State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China. mashuai@ioz.ac.cn.
¹⁰⁸ Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China. mashuai@ioz.ac.cn.
¹⁰⁹ Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, 100101, China. mashuai@ioz.ac.cn.
¹¹⁰ Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, 200241, China. xrma@bio.ecnu.edu.cn.
¹¹¹ Shanghai Key Laboratory of Maternal Fetal Medicine, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Frontier Science Center for Stem Cell Research, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, China. zhiyong_mao@tongji.edu.cn.
¹¹² The State Key Laboratory of Organ Failure Research, National Clinical Research Center of Kidney Disease, Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China. niejing@smu.edu.cn.
¹¹³ State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China. yaojin.peng@ioz.ac.cn.
¹¹⁴ University of Chinese Academy of Sciences, Beijing, 100049, China. yaojin.peng@ioz.ac.cn.
¹¹⁵ Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, 100101, China. yaojin.peng@ioz.ac.cn.
¹¹⁶ State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China. qujing@ioz.ac.cn.
¹¹⁷ University of Chinese Academy of Sciences, Beijing, 100049, China. qujing@ioz.ac.cn.
¹¹⁸ Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China. qujing@ioz.ac.cn.
¹¹⁹ Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, 100101, China. qujing@ioz.ac.cn.
¹²⁰ CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing, 100101, China. renjie@big.ac.cn.
¹²¹ University of Chinese Academy of Sciences, Beijing, 100049, China. renjie@big.ac.cn.
¹²² Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China. renjie@big.ac.cn.
¹²³ Shanghai Institute of Hematology, State Key Laboratory for Medical Genomics, National Research Center for Translational Medicine (Shanghai), International Center for Aging and Cancer, Collaborative Innovation Center of Hematology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. rbren@sjtu.edu.cn.
¹²⁴ International Center for Aging and Cancer, Hainan Medical University, Haikou, 571199, China. rbren@sjtu.edu.cn.
¹²⁵ University of Chinese Academy of Sciences, Beijing, 100049, China. songmoshi@ioz.ac.cn.
¹²⁶ State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China. songmoshi@ioz.ac.cn.
¹²⁷ Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China. songmoshi@ioz.ac.cn.
¹²⁸ Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, 100101, China. songmoshi@ioz.ac.cn.
¹²⁹ MOE Key Laboratory of Gene Function and Regulation, Guangzhou Key Laboratory of Healthy Aging Research, School of Life Sciences, Institute of Healthy Aging Research, Sun Yat-sen University, Guangzhou, 510275, China. songyanz@mail.sysu.edu.cn.
¹³⁰ Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, 510120, China. songyanz@mail.sysu.edu.cn.
¹³¹ Stem Cell Translational Research Center, Tongji Hospital, Tongji University School of Medicine, Shanghai, 200065, China. yi.eve.sun@gmail.com.
¹³² CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, Shanghai, 200031, China. sunyu@sibs.ac.cn.
¹³³ Department of Medicine and VAPSHCS, University of Washington, Seattle, WA, 98195, USA. sunyu@sibs.ac.cn.
¹³⁴ Human Phenome Institute, Fudan University, Shanghai, 201203, China. tianmei@fudan.edu.cn.
¹³⁵ Research Institute of Transplant Medicine, Organ Transplant Center, NHC Key Laboratory for Critical Care Medicine, Tianjin First Central Hospital, Nankai University, Tianjin, 300384, China. shusen@vip.163.com.
¹³⁶ Beijing Municipal Geriatric Medical Research Center, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China. wangsi@xwh.ccmu.edu.cn.
¹³⁷ Aging Translational Medicine Center, International Center for Aging and Cancer, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China. wangsi@xwh.ccmu.edu.cn.
¹³⁸ Advanced Innovation Center for Human Brain Protection, and National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing, 100053, China. wangsi@xwh.ccmu.edu.cn.
¹³⁹ School of Pharmaceutical Sciences, Tsinghua University, Beijing, 100084, China. xiawang@mail.tsinghua.edu.cn.
¹⁴⁰ Institute of Geriatrics, The second Medical Center, Beijing Key Laboratory of Aging and Geriatrics, National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, 100853, China. xnwang88@163.com.
¹⁴¹ Department of Neurology and Center for Clinical Neuroscience, Daping Hospital, Third Military Medical University, Chongqing, 400042, China. yanjiang_wang@tmmu.edu.cn.
¹⁴² Hepatobiliary and Pancreatic Center, Medical Research Center, Beijing Tsinghua Changgung Hospital, Beijing, 102218, China. wangyf2011126@126.com.
¹⁴³ Clinical Research Institute, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, 100730, China. catclw321@126.com.
¹⁴⁴ Center for Stem Cell Biologyand Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-sen University, Guangzhou, 510080, China. xiangp@mail.sysu.edu.cn.
¹⁴⁵ National-Local Joint Engineering Research Center for Stem Cells and Regenerative Medicine, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, China. xiangp@mail.sysu.edu.cn.
¹⁴⁶ CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, Shanghai, 200031, China. ycxiao@sibs.ac.cn.
¹⁴⁷ Peking University International Cancer Institute, Health Science Center, Peking University, Beijing, 100101, China. xiezhengwei@hsc.pku.edu.cn.
¹⁴⁸ Beijing & Qingdao Langu Pharmaceutical R&D Platform, Beijing Gigaceuticals Tech. Co. Ltd., Beijing, 100101, China. xiezhengwei@hsc.pku.edu.cn.
¹⁴⁹ Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, 201210, China. xudaichao@sioc.ac.cn.
¹⁵⁰ Department of Geriatrics, Medical Center on Aging of Shanghai Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. yj11254@rjh.com.cn.
¹⁵¹ International Laboratory in Hematology and Cancer, Shanghai Jiao Tong University School of Medicine/Ruijin Hospital, Shanghai, 200025, China. yj11254@rjh.com.cn.
¹⁵² Institute for Regenerative Medicine, Shanghai East Hospital, Frontier Science Center for Stem Cell Research, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, China. ryue@tongji.edu.cn.
¹⁵³ Gerontology Center of Hubei Province, Wuhan, 430000, China. ctzhang0425@163.com.
¹⁵⁴ Institute of Gerontology, Department of Geriatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. ctzhang0425@163.com.
¹⁵⁵ Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, China. zhanghongbo@mail.sysu.edu.cn.
¹⁵⁶ Advanced Medical Technology Center, The First Affiliated Hospital, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, China. zhanghongbo@mail.sysu.edu.cn.
¹⁵⁷ CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, Shanghai, 200031, China. zhangliang01@sibs.ac.cn.
¹⁵⁸ Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China. zhangliang01@sibs.ac.cn.
¹⁵⁹ CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing, 100101, China. zhangwq@big.ac.cn.
¹⁶⁰ University of Chinese Academy of Sciences, Beijing, 100049, China. zhangwq@big.ac.cn.
¹⁶¹ Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China. zhangwq@big.ac.cn.
¹⁶² Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory), Guangzhou, 510005, China. yongzhang@ibms.pumc.edu.cn.
¹⁶³ The State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, Beijing, 100005, China. yongzhang@ibms.pumc.edu.cn.
¹⁶⁴ Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen, 361102, China. yunzhang@xmu.edu.cn.
¹⁶⁵ Key Laboratory of Molecular Precision Medicine of Hunan Province and Center for Medical Genetics, Institute of Molecular Precision Medicine, Xiangya Hospital, Central South University, Changsha, 410078, China. zhangzhuohua@sklmg.edu.cn.
¹⁶⁶ Department of Neurosciences, Hengyang Medical School, University of South China, Hengyang, 421001, China. zhangzhuohua@sklmg.edu.cn.
¹⁶⁷ State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China. tbzhao@ioz.ac.cn.
¹⁶⁸ University of Chinese Academy of Sciences, Beijing, 100049, China. tbzhao@ioz.ac.cn.
¹⁶⁹ Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China. tbzhao@ioz.ac.cn.
¹⁷⁰ Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, 100101, China. tbzhao@ioz.ac.cn.
¹⁷¹ Optogenetics & Synthetic Biology Interdisciplinary Research Center, State Key Laboratory of Bioreactor Engineering, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China. yuzhengzhao@ecust.edu.cn.
¹⁷² Research Unit of New Techniques for Live-cell Metabolic Imaging, Chinese Academy of Medical Sciences, Beijing, 100730, China. yuzhengzhao@ecust.edu.cn.
¹⁷³ Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory), Guangzhou, 510005, China. dhzhu@pumc.edu.cn.
¹⁷⁴ The State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, Beijing, 100005, China. dhzhu@pumc.edu.cn.
¹⁷⁵ State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, 200031, China. zouwg94@sibcb.ac.cn.
¹⁷⁶ Shanghai Key Laboratory of Signaling and Disease Research, Laboratory of Receptor-Based Biomedicine, The Collaborative Innovation Center for Brain Science, School of Life Sciences and Technology, Tongji University, Shanghai, 200070, China. peigang@tongji.edu.cn.
¹⁷⁷ University of Chinese Academy of Sciences, Beijing, 100049, China. ghliu@ioz.ac.cn.
¹⁷⁸ State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China. ghliu@ioz.ac.cn.
¹⁷⁹ Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China. ghliu@ioz.ac.cn.
¹⁸⁰ Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, 100101, China. ghliu@ioz.ac.cn.
¹⁸¹ Advanced Innovation Center for Human Brain Protection, and National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing, 100053, China. ghliu@ioz.ac.cn.

^# Contributed equally.

PMID: 37076725
PMCID: PMC10115486
DOI: 10.1007/s11427-023-2305-0

Review

Biomarkers of aging

Aging Biomarker Consortium et al. Sci China Life Sci. 2023 May.

. 2023 May;66(5):893-1066.

doi: 10.1007/s11427-023-2305-0. Epub 2023 Apr 11.

Authors

Affiliations

¹ CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing, 100101, China.
² State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.
³ Department of Dermatology, Xiangya Hospital, Central South University, Changsha, 410008, China.
⁴ Hunan Key Laboratory of Aging Biology, Xiangya Hospital, Central South University, Changsha, 410008, China.
⁵ National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, 410008, China.
⁶ Clinic Center of Human Gene Research, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
⁷ Hubei Clinical Research Center of Metabolic and Cardiovascular Disease, Huazhong University of Science and Technology, Wuhan, 430022, China.
⁸ Hubei Key Laboratory of Metabolic Abnormalities and Vascular Aging, Huazhong University of Science and Technology, Wuhan, 430022, China.
⁹ Stem Cell Translational Research Center, Tongji Hospital, Tongji University School of Medicine, Shanghai, 200065, China.
¹⁰ Department of Nuclear Medicine, Daping Hospital, Third Military Medical University, Chongqing, 400042, China.
¹¹ CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China.
¹² Shanghai Key Laboratory of Maternal Fetal Medicine, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Frontier Science Center for Stem Cell Research, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, China.
¹³ The Department of Endovascular Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
¹⁴ Key Laboratory of Regenerative Medicine of Ministry of Education, Institute of Ageing and Regenerative Medicine, Jinan University, Guangzhou, 510632, China.
¹⁵ National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China.
¹⁶ University of Chinese Academy of Sciences, Beijing, 100049, China.
¹⁷ CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, Shanghai, 200031, China.
¹⁸ The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology of National Health Commission, Beijing, 100730, China.
¹⁹ School of Pharmaceutical Sciences, Tsinghua University, Beijing, 100084, China.
²⁰ State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.
²¹ Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China.
²² Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, 100101, China.
²³ Department of Neurology, First Affiliated Hospital, Shanxi Medical University, Taiyuan, 030001, China.
²⁴ Beijing Municipal Geriatric Medical Research Center, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China.
²⁵ Aging Translational Medicine Center, International Center for Aging and Cancer, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China.
²⁶ Advanced Innovation Center for Human Brain Protection, and National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing, 100053, China.
²⁷ Department of Neurology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230036, China.
²⁸ College of Life Sciences, TaiKang Center for Life and Medical Sciences, Wuhan University, Wuhan, 430072, China.
²⁹ Research Institute of Transplant Medicine, Organ Transplant Center, NHC Key Laboratory for Critical Care Medicine, Tianjin First Central Hospital, Nankai University, Tianjin, 300384, China.
³⁰ MOE Key Laboratory of Gene Function and Regulation, Guangzhou Key Laboratory of Healthy Aging Research, School of Life Sciences, Institute of Healthy Aging Research, Sun Yat-sen University, Guangzhou, 510275, China.
³¹ School of Life Sciences, Hainan University, Haikou, 570228, China.
³² Department of Systems Biomedical Sciences, School of Medicine, Jinan University, Guangzhou, 510632, China.
³³ School of Life Sciences, Xiamen University, Xiamen, 361102, China.
³⁴ The State Key Laboratory of Organ Failure Research, National Clinical Research Center of Kidney Disease, Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
³⁵ Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Center for Quantitative Biology (CQB), Peking University, Beijing, 100871, China.
³⁶ Shanghai Institute of Hematology, State Key Laboratory for Medical Genomics, National Research Center for Translational Medicine (Shanghai), International Center for Aging and Cancer, Collaborative Innovation Center of Hematology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
³⁷ National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.
³⁸ Peking University International Cancer Institute, Health Science Center, Peking University, Beijing, 100101, China.
³⁹ Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, State Key Laboratory of Biotherapy, West China Second University Hospital, Sichuan University, Chengdu, 610041, China.
⁴⁰ Institute for Regenerative Medicine, Shanghai East Hospital, Frontier Science Center for Stem Cell Research, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, China.
⁴¹ Clinical Research Institute, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, 100730, China.
⁴² Hepatobiliary and Pancreatic Center, Medical Research Center, Beijing Tsinghua Changgung Hospital, Beijing, 102218, China.
⁴³ Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, China.
⁴⁴ Advanced Medical Technology Center, The First Affiliated Hospital, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, China.
⁴⁵ Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory), Guangzhou, 510005, China.
⁴⁶ Center for Stem Cell Biologyand Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-sen University, Guangzhou, 510080, China.
⁴⁷ National-Local Joint Engineering Research Center for Stem Cells and Regenerative Medicine, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, China.
⁴⁸ CAS Center for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences, Kunming, 650223, China.
⁴⁹ State Key Laboratory of Genetic Resources and Evolution, Key Laboratory of Healthy Aging Research of Yunnan Province, Kunming Key Laboratory of Healthy Aging Study, KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, China.
⁵⁰ Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, 200241, China.
⁵¹ CAS Key Laboratory of Regenerative Biology, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University, Guangzhou, 510530, China.
⁵² State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, 200031, China.
⁵³ Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, 201210, China.
⁵⁴ Department of Geriatrics, Medical Center on Aging of Shanghai Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
⁵⁵ International Laboratory in Hematology and Cancer, Shanghai Jiao Tong University School of Medicine/Ruijin Hospital, Shanghai, 200025, China.
⁵⁶ Gerontology Center of Hubei Province, Wuhan, 430000, China.
⁵⁷ Institute of Gerontology, Department of Geriatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
⁵⁸ Department of Cardiology, The Second Medical Centre, Chinese PLA General Hospital, National Clinical Research Center for Geriatric Diseases, Beijing, 100853, China.
⁵⁹ Key Laboratory of Ministry of Education, School of Aerospace Medicine, Fourth Military Medical University, Xi'an, 710032, China.
⁶⁰ Optogenetics & Synthetic Biology Interdisciplinary Research Center, State Key Laboratory of Bioreactor Engineering, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China.
⁶¹ Research Unit of New Techniques for Live-cell Metabolic Imaging, Chinese Academy of Medical Sciences, Beijing, 100730, China.
⁶² Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, 410008, China.
⁶³ Department of Nuclear Medicine and PET Center, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, 310009, China.
⁶⁴ Department of Genetics and Cell Biology, College of Life Science, Nankai University, Tianjin, 300071, China.
⁶⁵ Haihe Laboratory of Cell Ecosystem, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, 300020, China.
⁶⁶ Department of Cardiology, The Second Medical Centre, Chinese PLA General Hospital, National Clinical Research Center for Geriatric Diseases, Beijing, 100853, China. fengcao8828@163.com.
⁶⁷ State Key Laboratory of Biotherapy, West China Second University Hospital, Sichuan University, Chengdu, 610041, China. zhongweicao@scu.edu.cn.
⁶⁸ National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China. pbchan@hotmail.com.
⁶⁹ National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China. changchen@ibp.ac.cn.
⁷⁰ Department of Microbiology and Immunology, School of Medicine, Jinan University, Guangzhou, 510632, China. guobingchen@jnu.edu.cn.
⁷¹ Guangdong-Hong Kong-Macau Great Bay Area Geroscience Joint Laboratory, Guangzhou, 510000, China. guobingchen@jnu.edu.cn.
⁷² Department of Biochemistryand Molecular Biology, State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100005, China. chenhouzao@ibms.cams.cn.
⁷³ Peking University Research Center on Aging, Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, Department of Biochemistry and Molecular Biology, Department of Integration of Chinese and Western Medicine, School of Basic Medical Science, Peking University, Beijing, 100191, China. cjbiochem@bjmu.edu.cn.
⁷⁴ CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing, 100101, China. ciwm@big.ac.cn.
⁷⁵ State Key Laboratory of Biotherapy, West China Second University Hospital, Sichuan University, Chengdu, 610041, China. dingbisen@scu.edu.cn.
⁷⁶ CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China. qrding@sibs.ac.cn.
⁷⁷ Key Laboratory of Ministry of Education, School of Aerospace Medicine, Fourth Military Medical University, Xi'an, 710032, China. fgao@fmmu.edu.cn.
⁷⁸ Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Center for Quantitative Biology (CQB), Peking University, Beijing, 100871, China. jackie.han@pku.edu.cn.
⁷⁹ Clinic Center of Human Gene Research, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. huangkai1@hust.edu.cn.
⁸⁰ Hubei Clinical Research Center of Metabolic and Cardiovascular Disease, Huazhong University of Science and Technology, Wuhan, 430022, China. huangkai1@hust.edu.cn.
⁸¹ Hubei Key Laboratory of Metabolic Abnormalities and Vascular Aging, Huazhong University of Science and Technology, Wuhan, 430022, China. huangkai1@hust.edu.cn.
⁸² Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. huangkai1@hust.edu.cn.
⁸³ Key Laboratory of Regenerative Medicine of Ministry of Education, Institute of Ageing and Regenerative Medicine, Jinan University, Guangzhou, 510632, China. zhenyuju@163.com.
⁸⁴ CAS Center for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences, Kunming, 650223, China. kongqp@mail.kiz.ac.cn.
⁸⁵ State Key Laboratory of Genetic Resources and Evolution, Key Laboratory of Healthy Aging Research of Yunnan Province, Kunming Key Laboratory of Healthy Aging Study, KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, China. kongqp@mail.kiz.ac.cn.
⁸⁶ Department of Dermatology, Xiangya Hospital, Central South University, Changsha, 410008, China. liji_xy@csu.edu.cn.
⁸⁷ Hunan Key Laboratory of Aging Biology, Xiangya Hospital, Central South University, Changsha, 410008, China. liji_xy@csu.edu.cn.
⁸⁸ National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, 410008, China. liji_xy@csu.edu.cn.
⁸⁹ The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology of National Health Commission, Beijing, 100730, China. Lijian@bjhmoh.cn.
⁹⁰ State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China. xinli@ioz.ac.cn.
⁹¹ University of Chinese Academy of Sciences, Beijing, 100049, China. xinli@ioz.ac.cn.
⁹² Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China. xinli@ioz.ac.cn.
⁹³ Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, 100101, China. xinli@ioz.ac.cn.
⁹⁴ School of Basic Medical Sciences, Shenzhen University Medical School, Shenzhen, 518060, China. ppliew@szu.edu.cn.
⁹⁵ Metabolic Syndrome Research Center, The Second Xiangya Hospital, Central South Unversity, Changsha, 410011, China. liuf001@csu.edu.cn.
⁹⁶ Department of Genetics and Cell Biology, College of Life Science, Nankai University, Tianjin, 300071, China. liulin@nankai.edu.cn.
⁹⁷ Haihe Laboratory of Cell Ecosystem, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, 300020, China. liulin@nankai.edu.cn.
⁹⁸ Institute of Translational Medicine, Tianjin Union Medical Center, Nankai University, Tianjin, 300000, China. liulin@nankai.edu.cn.
⁹⁹ State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin, 300350, China. liulin@nankai.edu.cn.
¹⁰⁰ Department of Neurology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230036, China. liuq2012@ustc.edu.cn.
¹⁰¹ Department of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, 300052, China. qliu@tmu.edu.cn.
¹⁰² Tianjin Institute of Immunology, Tianjin Medical University, Tianjin, 300070, China. qliu@tmu.edu.cn.
¹⁰³ CAS Key Laboratory of Regenerative Biology, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University, Guangzhou, 510530, China. liu_xingguo@gibh.ac.cn.
¹⁰⁴ College of Life Sciences, TaiKang Center for Life and Medical Sciences, Wuhan University, Wuhan, 430072, China. liuyong31279@whu.edu.cn.
¹⁰⁵ Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, 410008, China. xianghangluo@csu.edu.cn.
¹⁰⁶ University of Chinese Academy of Sciences, Beijing, 100049, China. mashuai@ioz.ac.cn.
¹⁰⁷ State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China. mashuai@ioz.ac.cn.
¹⁰⁸ Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China. mashuai@ioz.ac.cn.
¹⁰⁹ Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, 100101, China. mashuai@ioz.ac.cn.
¹¹⁰ Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, 200241, China. xrma@bio.ecnu.edu.cn.
¹¹¹ Shanghai Key Laboratory of Maternal Fetal Medicine, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Frontier Science Center for Stem Cell Research, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, China. zhiyong_mao@tongji.edu.cn.
¹¹² The State Key Laboratory of Organ Failure Research, National Clinical Research Center of Kidney Disease, Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China. niejing@smu.edu.cn.
¹¹³ State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China. yaojin.peng@ioz.ac.cn.
¹¹⁴ University of Chinese Academy of Sciences, Beijing, 100049, China. yaojin.peng@ioz.ac.cn.
¹¹⁵ Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, 100101, China. yaojin.peng@ioz.ac.cn.
¹¹⁶ State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China. qujing@ioz.ac.cn.
¹¹⁷ University of Chinese Academy of Sciences, Beijing, 100049, China. qujing@ioz.ac.cn.
¹¹⁸ Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China. qujing@ioz.ac.cn.
¹¹⁹ Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, 100101, China. qujing@ioz.ac.cn.
¹²⁰ CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing, 100101, China. renjie@big.ac.cn.
¹²¹ University of Chinese Academy of Sciences, Beijing, 100049, China. renjie@big.ac.cn.
¹²² Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China. renjie@big.ac.cn.
¹²³ Shanghai Institute of Hematology, State Key Laboratory for Medical Genomics, National Research Center for Translational Medicine (Shanghai), International Center for Aging and Cancer, Collaborative Innovation Center of Hematology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. rbren@sjtu.edu.cn.
¹²⁴ International Center for Aging and Cancer, Hainan Medical University, Haikou, 571199, China. rbren@sjtu.edu.cn.
¹²⁵ University of Chinese Academy of Sciences, Beijing, 100049, China. songmoshi@ioz.ac.cn.
¹²⁶ State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China. songmoshi@ioz.ac.cn.
¹²⁷ Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China. songmoshi@ioz.ac.cn.
¹²⁸ Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, 100101, China. songmoshi@ioz.ac.cn.
¹²⁹ MOE Key Laboratory of Gene Function and Regulation, Guangzhou Key Laboratory of Healthy Aging Research, School of Life Sciences, Institute of Healthy Aging Research, Sun Yat-sen University, Guangzhou, 510275, China. songyanz@mail.sysu.edu.cn.
¹³⁰ Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, 510120, China. songyanz@mail.sysu.edu.cn.
¹³¹ Stem Cell Translational Research Center, Tongji Hospital, Tongji University School of Medicine, Shanghai, 200065, China. yi.eve.sun@gmail.com.
¹³² CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, Shanghai, 200031, China. sunyu@sibs.ac.cn.
¹³³ Department of Medicine and VAPSHCS, University of Washington, Seattle, WA, 98195, USA. sunyu@sibs.ac.cn.
¹³⁴ Human Phenome Institute, Fudan University, Shanghai, 201203, China. tianmei@fudan.edu.cn.
¹³⁵ Research Institute of Transplant Medicine, Organ Transplant Center, NHC Key Laboratory for Critical Care Medicine, Tianjin First Central Hospital, Nankai University, Tianjin, 300384, China. shusen@vip.163.com.
¹³⁶ Beijing Municipal Geriatric Medical Research Center, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China. wangsi@xwh.ccmu.edu.cn.
¹³⁷ Aging Translational Medicine Center, International Center for Aging and Cancer, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China. wangsi@xwh.ccmu.edu.cn.
¹³⁸ Advanced Innovation Center for Human Brain Protection, and National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing, 100053, China. wangsi@xwh.ccmu.edu.cn.
¹³⁹ School of Pharmaceutical Sciences, Tsinghua University, Beijing, 100084, China. xiawang@mail.tsinghua.edu.cn.
¹⁴⁰ Institute of Geriatrics, The second Medical Center, Beijing Key Laboratory of Aging and Geriatrics, National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, 100853, China. xnwang88@163.com.
¹⁴¹ Department of Neurology and Center for Clinical Neuroscience, Daping Hospital, Third Military Medical University, Chongqing, 400042, China. yanjiang_wang@tmmu.edu.cn.
¹⁴² Hepatobiliary and Pancreatic Center, Medical Research Center, Beijing Tsinghua Changgung Hospital, Beijing, 102218, China. wangyf2011126@126.com.
¹⁴³ Clinical Research Institute, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, 100730, China. catclw321@126.com.
¹⁴⁴ Center for Stem Cell Biologyand Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-sen University, Guangzhou, 510080, China. xiangp@mail.sysu.edu.cn.
¹⁴⁵ National-Local Joint Engineering Research Center for Stem Cells and Regenerative Medicine, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, China. xiangp@mail.sysu.edu.cn.
¹⁴⁶ CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, Shanghai, 200031, China. ycxiao@sibs.ac.cn.
¹⁴⁷ Peking University International Cancer Institute, Health Science Center, Peking University, Beijing, 100101, China. xiezhengwei@hsc.pku.edu.cn.
¹⁴⁸ Beijing & Qingdao Langu Pharmaceutical R&D Platform, Beijing Gigaceuticals Tech. Co. Ltd., Beijing, 100101, China. xiezhengwei@hsc.pku.edu.cn.
¹⁴⁹ Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, 201210, China. xudaichao@sioc.ac.cn.
¹⁵⁰ Department of Geriatrics, Medical Center on Aging of Shanghai Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. yj11254@rjh.com.cn.
¹⁵¹ International Laboratory in Hematology and Cancer, Shanghai Jiao Tong University School of Medicine/Ruijin Hospital, Shanghai, 200025, China. yj11254@rjh.com.cn.
¹⁵² Institute for Regenerative Medicine, Shanghai East Hospital, Frontier Science Center for Stem Cell Research, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, China. ryue@tongji.edu.cn.
¹⁵³ Gerontology Center of Hubei Province, Wuhan, 430000, China. ctzhang0425@163.com.
¹⁵⁴ Institute of Gerontology, Department of Geriatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. ctzhang0425@163.com.
¹⁵⁵ Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, China. zhanghongbo@mail.sysu.edu.cn.
¹⁵⁶ Advanced Medical Technology Center, The First Affiliated Hospital, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, China. zhanghongbo@mail.sysu.edu.cn.
¹⁵⁷ CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, Shanghai, 200031, China. zhangliang01@sibs.ac.cn.
¹⁵⁸ Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China. zhangliang01@sibs.ac.cn.
¹⁵⁹ CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing, 100101, China. zhangwq@big.ac.cn.
¹⁶⁰ University of Chinese Academy of Sciences, Beijing, 100049, China. zhangwq@big.ac.cn.
¹⁶¹ Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China. zhangwq@big.ac.cn.
¹⁶² Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory), Guangzhou, 510005, China. yongzhang@ibms.pumc.edu.cn.
¹⁶³ The State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, Beijing, 100005, China. yongzhang@ibms.pumc.edu.cn.
¹⁶⁴ Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen, 361102, China. yunzhang@xmu.edu.cn.
¹⁶⁵ Key Laboratory of Molecular Precision Medicine of Hunan Province and Center for Medical Genetics, Institute of Molecular Precision Medicine, Xiangya Hospital, Central South University, Changsha, 410078, China. zhangzhuohua@sklmg.edu.cn.
¹⁶⁶ Department of Neurosciences, Hengyang Medical School, University of South China, Hengyang, 421001, China. zhangzhuohua@sklmg.edu.cn.
¹⁶⁷ State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China. tbzhao@ioz.ac.cn.
¹⁶⁸ University of Chinese Academy of Sciences, Beijing, 100049, China. tbzhao@ioz.ac.cn.
¹⁶⁹ Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China. tbzhao@ioz.ac.cn.
¹⁷⁰ Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, 100101, China. tbzhao@ioz.ac.cn.
¹⁷¹ Optogenetics & Synthetic Biology Interdisciplinary Research Center, State Key Laboratory of Bioreactor Engineering, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China. yuzhengzhao@ecust.edu.cn.
¹⁷² Research Unit of New Techniques for Live-cell Metabolic Imaging, Chinese Academy of Medical Sciences, Beijing, 100730, China. yuzhengzhao@ecust.edu.cn.
¹⁷³ Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory), Guangzhou, 510005, China. dhzhu@pumc.edu.cn.
¹⁷⁴ The State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, Beijing, 100005, China. dhzhu@pumc.edu.cn.
¹⁷⁵ State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, 200031, China. zouwg94@sibcb.ac.cn.
¹⁷⁶ Shanghai Key Laboratory of Signaling and Disease Research, Laboratory of Receptor-Based Biomedicine, The Collaborative Innovation Center for Brain Science, School of Life Sciences and Technology, Tongji University, Shanghai, 200070, China. peigang@tongji.edu.cn.
¹⁷⁷ University of Chinese Academy of Sciences, Beijing, 100049, China. ghliu@ioz.ac.cn.
¹⁷⁸ State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China. ghliu@ioz.ac.cn.
¹⁷⁹ Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China. ghliu@ioz.ac.cn.
¹⁸⁰ Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, 100101, China. ghliu@ioz.ac.cn.
¹⁸¹ Advanced Innovation Center for Human Brain Protection, and National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing, 100053, China. ghliu@ioz.ac.cn.

^# Contributed equally.

PMID: 37076725
PMCID: PMC10115486
DOI: 10.1007/s11427-023-2305-0

Abstract

Aging biomarkers are a combination of biological parameters to (i) assess age-related changes, (ii) track the physiological aging process, and (iii) predict the transition into a pathological status. Although a broad spectrum of aging biomarkers has been developed, their potential uses and limitations remain poorly characterized. An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research: How old are we? Why do we get old? And how can we age slower? This review aims to address this need. Here, we summarize our current knowledge of biomarkers developed for cellular, organ, and organismal levels of aging, comprising six pillars: physiological characteristics, medical imaging, histological features, cellular alterations, molecular changes, and secretory factors. To fulfill all these requisites, we propose that aging biomarkers should qualify for being specific, systemic, and clinically relevant.

Keywords: aging; biomarker; clock; senescence.

PubMed Disclaimer

Cited by

New Insights into the Pro-Inflammatory and Osteoclastogenic Profile of Circulating Monocytes in Osteoarthritis Patients.
Guillem-Llobat P, Marín M, Rouleau M, Silvestre A, Blin-Wakkach C, Ferrándiz ML, Guillén MI, Ibáñez L. Guillem-Llobat P, et al. Int J Mol Sci. 2024 Jan 30;25(3):1710. doi: 10.3390/ijms25031710. Int J Mol Sci. 2024. PMID: 38338988 Free PMC article.
Identification of prospective aging drug targets via Mendelian randomization analysis.
Mao R, Li J, Xiao W. Mao R, et al. Aging Cell. 2024 Jul;23(7):e14171. doi: 10.1111/acel.14171. Epub 2024 Apr 4. Aging Cell. 2024. PMID: 38572516 Free PMC article.
SenoIndex: S100A8/S100A9 as a novel aging biomarker.
Zhang B, Yan H, Liu X, Sun L, Ma S, Wang S, Qu J, Liu GH, Zhang W. Zhang B, et al. Life Med. 2023 Jun 13;2(4):lnad022. doi: 10.1093/lifemedi/lnad022. eCollection 2023 Aug. Life Med. 2023. PMID: 39872551 Free PMC article. No abstract available.
Combination of Creatinine with Inflammatory Biomarkers (PCT, CRP, hsCRP) for Predicting Postoperative ICU Admissions for Elderly Patients.
Chen Y, Teng Y, Peng X, Zhu T, Liu J, Ou M, Hao X. Chen Y, et al. Adv Ther. 2024 Jul;41(7):2776-2790. doi: 10.1007/s12325-024-02874-1. Epub 2024 May 14. Adv Ther. 2024. PMID: 38743240 Free PMC article.
Single-Cell Transcriptomics Uncovers Core Signature for Regulating Mitochondrial Homeostasis During Testicular Ageing.
Xu W, Huang Q, Qi Y, Hu Q, Shen C, Chen X, Li J, Xia Q, Pan Z, Zhang Y, Han G, Huang J, Liu Y, Cao Z, Zheng Y, Zheng B, Gu Z, Yu J, Sun C. Xu W, et al. Cell Prolif. 2025 May;58(5):e13797. doi: 10.1111/cpr.13797. Epub 2024 Dec 27. Cell Prolif. 2025. PMID: 39731228 Free PMC article.

See all "Cited by" articles

References

1. Abdallah P, Luciano P, Runge KW, Lisby M, Géli V, Gilson E, Teixeira MT. A two-step model for senescence triggered by a single critically short telomere. Nat Cell Biol. 2009;11:988–993. doi: 10.1038/ncb1911. - DOI - PMC - PubMed
1. Abou R, Leung M, Tonsbeek AM, Podlesnikar T, Maan AC, Schalij MJ, Ajmone Marsan N, Delgado V, Bax JJ. Effect of aging on left atrial compliance and electromechanical properties in subjects without structural heart disease. Am J Cardiol. 2017;120:140–147. doi: 10.1016/j.amjcard.2017.03.243. - DOI - PubMed
1. Acer E, Kaya Erdogan H, Kocatürk E, Saracoğlu ZN, Alataş ö, Bilgin M. Evaluation of oxidative stress and psychoemotional status in premature hair graying. J Cosmet Dermatol. 2020;19:3403–3401. doi: 10.1111/jocd.13428. - DOI - PubMed
1. Acosta-Rodríguez VA, Rijo-Ferreira F, Green CB, Takahashi JS. Importance of circadian timing for aging and longevity. Nat Commun. 2021;12:2862. doi: 10.1038/s41467-021-22922-6. - DOI - PMC - PubMed
1. Acosta JC, Banito A, Wuestefeld T, Georgilis A, Janich P, Morton J P, Athineos D, Kang TW, Lasitschka F, Andrulis M, et al. A complex secretory program orchestrated by the inflammasome controls paracrine senescence. Nat Cell Biol. 2013;15:918–990. doi: 10.1038/ncb2784. - DOI - PMC - PubMed

Publication types

Actions

MeSH terms

Actions
Actions
Actions

Substances

Actions

LinkOut - more resources

Full Text Sources

[1] Abdallah P, Luciano P, Runge KW, Lisby M, Géli V, Gilson E, Teixeira MT. A two-step model for senescence triggered by a single critically short telomere. Nat Cell Biol. 2009;11:988–993. doi: 10.1038/ncb1911. - DOI - PMC - PubMed

[2] Abdallah P, Luciano P, Runge KW, Lisby M, Géli V, Gilson E, Teixeira MT. A two-step model for senescence triggered by a single critically short telomere. Nat Cell Biol. 2009;11:988–993. doi: 10.1038/ncb1911. - DOI - PMC - PubMed

[3] Abou R, Leung M, Tonsbeek AM, Podlesnikar T, Maan AC, Schalij MJ, Ajmone Marsan N, Delgado V, Bax JJ. Effect of aging on left atrial compliance and electromechanical properties in subjects without structural heart disease. Am J Cardiol. 2017;120:140–147. doi: 10.1016/j.amjcard.2017.03.243. - DOI - PubMed

[4] Abou R, Leung M, Tonsbeek AM, Podlesnikar T, Maan AC, Schalij MJ, Ajmone Marsan N, Delgado V, Bax JJ. Effect of aging on left atrial compliance and electromechanical properties in subjects without structural heart disease. Am J Cardiol. 2017;120:140–147. doi: 10.1016/j.amjcard.2017.03.243. - DOI - PubMed

[5] Acer E, Kaya Erdogan H, Kocatürk E, Saracoğlu ZN, Alataş ö, Bilgin M. Evaluation of oxidative stress and psychoemotional status in premature hair graying. J Cosmet Dermatol. 2020;19:3403–3401. doi: 10.1111/jocd.13428. - DOI - PubMed

[6] Acer E, Kaya Erdogan H, Kocatürk E, Saracoğlu ZN, Alataş ö, Bilgin M. Evaluation of oxidative stress and psychoemotional status in premature hair graying. J Cosmet Dermatol. 2020;19:3403–3401. doi: 10.1111/jocd.13428. - DOI - PubMed

[7] Acosta-Rodríguez VA, Rijo-Ferreira F, Green CB, Takahashi JS. Importance of circadian timing for aging and longevity. Nat Commun. 2021;12:2862. doi: 10.1038/s41467-021-22922-6. - DOI - PMC - PubMed

[8] Acosta-Rodríguez VA, Rijo-Ferreira F, Green CB, Takahashi JS. Importance of circadian timing for aging and longevity. Nat Commun. 2021;12:2862. doi: 10.1038/s41467-021-22922-6. - DOI - PMC - PubMed

[9] Acosta JC, Banito A, Wuestefeld T, Georgilis A, Janich P, Morton J P, Athineos D, Kang TW, Lasitschka F, Andrulis M, et al. A complex secretory program orchestrated by the inflammasome controls paracrine senescence. Nat Cell Biol. 2013;15:918–990. doi: 10.1038/ncb2784. - DOI - PMC - PubMed

[10] Acosta JC, Banito A, Wuestefeld T, Georgilis A, Janich P, Morton J P, Athineos D, Kang TW, Lasitschka F, Andrulis M, et al. A complex secretory program orchestrated by the inflammasome controls paracrine senescence. Nat Cell Biol. 2013;15:918–990. doi: 10.1038/ncb2784. - DOI - PMC - PubMed

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Biomarkers of aging

Affiliations

Biomarkers of aging

Authors

Affiliations

Abstract

Similar articles

Cited by

References

Publication types

MeSH terms

Substances

LinkOut - more resources

Full Text Sources

Abstract

Similar articles

Cited by

References

Publication types

MeSH terms

Substances

Related information

LinkOut - more resources

Full Text Sources