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. 2023 Apr 20;19(1):31.
doi: 10.1186/s13223-023-00788-1.

Delayed hypersensitivity reaction to cosmetic filler following two COVID-19 vaccinations and infection

Safaa Azzouz  1 , Derek Lanoue  2 , Katéri Champagne  3 , Genevieve Genest  2
Affiliations

Delayed hypersensitivity reaction to cosmetic filler following two COVID-19 vaccinations and infection

Safaa Azzouz et al. Allergy Asthma Clin Immunol. .

Abstract

Background: With ongoing COVID-19 vaccination schedules and the popularity of cosmetic fillers, it is important to examine and record associated adverse reactions to a more general audience of health care professionals. Case reports exist in subspecialty journals outlining reactions after SARS-CoV-2 infection and vaccination. This is one of the first cases published in Canada, and it highlights priorities and challenges faced by physicians in assessing and managing patients presenting with adverse reactions post vaccination.

Case presentation: We present a case of a 43 -year-old women with delayed type 4 hypersensitivity reaction to hyaluronic acid cosmetic filler triggered by COVID-19 mRNA vaccination. We outline the clinical presentation, diagnosis, complications, and treatment of a late inflammatory reaction to hyaluronic acid filler and highlight the treatment priorities for clinicians faced with similar presentations.

Conclusion: The differential diagnosis of delayed onset nodules formation post filler injection is broad and includes redistribution of fillers, inflammatory reaction to biofilm, and delayed hypersensitivity reaction. As result, in order to make the right diagnosis, administer the appropriate treatment and achieve great cosmetic results, we highly recommend seeking expert opinion from dermatologist, plastic surgeon and allergist immunologist in a timely manner.

Keywords: COVID vaccine; Cosmetic filler; Delayed hypersensitivity reactions; Hyaluronic acid injection.

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Conflict of interest statement

No conflict of interest.

Figures

Fig. 1
Fig. 1
Raised inflamed erythematous papule involving the left cheek
Fig. 2
Fig. 2
Multiples areas of induration in keeping with delayed onset nodules
Fig. 3
Fig. 3
Positive delayed read intradermal skin testing to Volux /Volbella with lidocaine HA products by Juvederm
See this image and copyright information in PMC

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