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Review
. 2023 Apr 19;21(1):79.
doi: 10.1186/s12964-023-01106-3.

MiRNA-93: a novel signature in human disorders and drug resistance

Bashdar Mahmud Hussen  1 , Snur Rasool Abdullah  2 , Mohammed Fatih Rasul  3 , Zanko Hassan Jawhar  2 , Goran Sedeeq Hama Faraj  4 , Arda Kiani  5 , Mohammad Taheri  6   7
Affiliations
Review

MiRNA-93: a novel signature in human disorders and drug resistance

Bashdar Mahmud Hussen et al. Cell Commun Signal. .

Abstract

miRNA-93 is a member of the miR-106b-25 family and is encoded by a gene on chromosome 7q22.1. They play a role in the etiology of various diseases, including cancer, Parkinson's disease, hepatic injury, osteoarthritis, acute myocardial infarction, atherosclerosis, rheumatoid arthritis, and chronic kidney disease. Different studies have found that this miRNA has opposing roles in the context of cancer. Recently, miRNA-93 has been downregulated in breast cancer, gastric cancer, colorectal cancer, pancreatic cancer, bladder cancer, cervical cancer, and renal cancer. However, miRNA-93 is up-regulated in a wide variety of malignancies, such as lung, colorectal, glioma, prostate, osteosarcoma, and hepatocellular carcinoma. The aim of the current review is to provide an overview of miRNA-93's function in cancer disorder progression and non-cancer disorders, with a focus on dysregulated signaling pathways. We also give an overview of this miRNA's function as a biomarker of prognosis in cancer and emphasize how it contributes to drug resistance based on in vivo, in vitro, and human studies. Video Abstract.

Keywords: Biomarker; Cancer; Drug resistance; miRNA-93.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
The expression patterns and pivotal roles of miRNA-93 in tumor networks are graphically depicted, along with its signaling pathways in different types of cancer
Fig. 2
Fig. 2
MiRNA-93's role in animal cancer models. By interacting with specific targets, miR-93-5p makes tumors grow rapidly in a xenograft mouse model of different types of cancer, such as, miR-93 directly inhibits the expression of DAB2 in NSCLC. Targeting PEDF made RCC cells multiply and targeting NRF2 inhibits cells from dying and made more colonies form in BC
Fig. 3
Fig. 3
The function of miRNA-93 in human Retinoblastoma and Osteosarcoma. In a clinical sample of retinoblastoma and osteosarcoma, miRNA-93-5p interacts with particular targets to cause tumors to grow quickly. A Through the PI3K/AKT signaling pathway, miRNA-93 directly reduces the expression of PTEN, a tumor suppressor gene, which promotes the growth of tumors in RB. B The expression of FZD7, which promotes tumor growth, is stimulated by the Wnt/B-catenin pathway and the rising amount of lncRNA AWPPH, which sponges miRNA-93
Fig. 4
Fig. 4
The diagram depicts the primary roles that miRNA-93 plays in the pathophysiology of non-cancerous illnesses. The expression level of miRNA-93, which modulates a large number of signaling pathways, has a role in the progression of a wide variety of diseases
Fig. 5
Fig. 5
Illustration shows the role of miRNA-93 in drug resistance through different mechanisms such as alteration of drug concentration, drug target, cell cycle and apoptosis, and inhibition of DNA damage repair mechanisms
See this image and copyright information in PMC

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