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Case Reports
. 2023 Mar 29:32:e01751.
doi: 10.1016/j.idcr.2023.e01751. eCollection 2023.

Chorioamnionitis and early pregnancy loss caused by ampicillin-resistant non-typeable Haemophilus influenzae

Yuji Nishihara  1 , Nobuyasu Hirai  1 , Takahiro Sekine  1 , Nao Okuda  1 , Tomoko Nishimura  1 , Hiroyuki Fujikura  1 , Ryutaro Furukawa  1 , Natsuko Imakita  1 , Tatsuya Fukumori  1 , Taku Ogawa  1 , Yuki Suzuki  2 , Ryuichi Nakano  2 , Akiyo Nakano  2 , Hisakazu Yano  2 , Kei Kasahara  1
Affiliations
Case Reports

Chorioamnionitis and early pregnancy loss caused by ampicillin-resistant non-typeable Haemophilus influenzae

Yuji Nishihara et al. IDCases. .

Abstract

Haemophilus influenzae can cause intra-amniotic infection and early pregnancy loss. The mode of transmission and risk factors for H. influenzae uterine cavity infections are unknown. Here, we present the case of chorioamnionitis caused by ampicillin-resistant H. influenzae in a 32-year-old Japanese woman at 16 weeks of gestation. Despite empirical treatment, including ampicillin, as recommended by the current guidelines, she had fetal loss. The antimicrobial regimen was changed to ceftriaxone, and the treatment was completed without complications. Although the prevalence and risk factors for chorioamnionitis caused by ampicillin-resistant H. influenzae are unknown, clinicians need to recognize H. influenzae as a potentially drug-resistant and lethal bacterium for pregnant women.

Keywords: Chorioamnionitis; Fetal loss; Haemophilus influenzae; Oral transmission; Pregnancy.

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Conflict of interest statement

None.

Figures

Fig. 1
Fig. 1
Vaginal Gram stain upon admission. Small Gram-negative coccobacilli with leukocyte phagocytosis (arrows) are evident.
Fig. 2
Fig. 2
Histopathological placental images. H and E staining showing diffuse neutrophil infiltration at the chorion membrane (arrows) and a decidual abscess (black asterisks), consistent with stage 2 acute chorioamnionitis.
See this image and copyright information in PMC

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