Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Apr 18;16(4):645-651.
doi: 10.18240/ijo.2023.04.20. eCollection 2023.

Recent progress in N6-methyladenosine modification in ocular surface diseases

Wei Wang  1 , Jun Zou  1
Affiliations
Review

Recent progress in N6-methyladenosine modification in ocular surface diseases

Wei Wang et al. Int J Ophthalmol. .

Abstract

N6-methyladenosine (m6A) modification is a reversible process promoted by "writers", inhibited by "erasers", and processed by "readers". During the last decade, increasing emphasis has been placed on the underlying roles of m6A modification owing to their great importance in biological significance. The abnormal regulation of m6A modification will lead to aberrant cellular behavior and various diseases. Recently, studies have demonstrated that m6A modification is closely associated with the genesis and progression of ocular surface diseases (OSDs). This review focus on the role of m6A modification and research progress in OSDs including fungal keratitis, herpes simplex keratitis, immune-related keratoconjunctival diseases, pterygium, ocular chemical burns, and Graves' ophthalmopathy, which may provide new insights into and prospective applications for OSDs.

Keywords: N6-methyladenosine; epigenetics; m6A modification; ocular surface diseases.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Gipson IK. The ocular surface: the challenge to enable and protect vision: the Friedenwald lecture. Invest Ophthalmol Vis Sci. 2007;48(10):4390; 4391–4390; 4398. - PMC - PubMed
    1. Kacham S, Bhure TS, Eswaramoorthy SD, Naik G, Rath SN, Parcha SR, Basu, Sangwan VS, Shukla S. Human umbilical cord-derived mesenchymal stem cells promote corneal epithelial repair in vitro. Cells. 2021;10(5):1254. - PMC - PubMed
    1. Jiang XL, Liu BY, Nie Z, Duan LC, Xiong QX, Jin ZX, Yang CP, Chen YB. The role of m6A modification in the biological functions and diseases. Signal Transduct Target Ther. 2021;6(1):74. - PMC - PubMed
    1. Zhuang YY, Liu HJ, Song X, Ju Y, Peng H. A linear regression predictor for identifying n6-methyladenosine sites using frequent gapped k-mer pattern. Mol Ther Nucleic Acids. 2019;18:673–680. - PMC - PubMed
    1. Qu JW, Yan HM, Hou YF, Cao W, Liu Y, Zhang EF, He JS, Cai Z. RNA demethylase ALKBH5 in cancer: from mechanisms to therapeutic potential. J Hematol Oncol. 2022;15(1):8. - PMC - PubMed

LinkOut - more resources