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Review
. 2023 Jan-Jun;23(6):565-573.
doi: 10.1080/14712598.2023.2203811. Epub 2023 Apr 20.

Recent advances in stem cell therapy for erectile dysfunction: a narrative review

Bohan Wang  1   2 , Wenjun Gao  2 , Micha Y Zheng  1 , Guiting Lin  1 , Tom F Lue  1
Affiliations
Review

Recent advances in stem cell therapy for erectile dysfunction: a narrative review

Bohan Wang et al. Expert Opin Biol Ther. 2023 Jan-Jun.

Abstract

Introduction: While phosphodiesterase type 5 inhibitors (PDE5is) and others are used to treat Erectile dysfunction (ED), many patients are either unresponsive or resistant to it. Stem cell therapy (SCT) is a promising alternative approach. Numerous preclinical trials have demonstrated improved erectile function in animal models using SCT, although the number of clinical trials investigating SCT for men with ED is limited. Nonetheless, findings from human clinical trials suggest that SCT may be a useful treatment option.

Areas covered: Biomedical literature, including PubMed, ClinicalTrials.gov, and European Union Clinical Trials Registry, were analyzed to summarize and synthesize information on stem cell therapy for ED in this narrative review. The achievements in preclinical and clinical evaluations are presented and critically analyzed.

Expert opinion: SCT has demonstrated some benefits in improving erectile function, while further studies are urgently needed. Such studies would provide valuable insights into the optimal use of stem cell therapy and its potential as a therapeutic option for ED. Taking advantage of different mechanisms of action involved in various regenerative therapies, combination therapies such as SCT and low-energy shock waves or platelet-rich plasma may provide a more effective therapy and warrant further research.

Keywords: Erectile dysfunction; clinical trial; restorative therapy; side effects; stem cell therapy.

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Conflict of interest statement

Declaration of interest

TF Lue is a consultant to and a shareholder of the Acoustic Wave Cell Therapy, Inc. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

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