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Review
. 2023 Jun 1;36(3):175-184.
doi: 10.1097/WCO.0000000000001155. Epub 2023 Apr 17.

Diagnosing viral encephalitis and emerging concepts

Heather Y F Yong  1 , Daniel M Pastula  2   3 , Ronak K Kapadia  1
Affiliations
Review

Diagnosing viral encephalitis and emerging concepts

Heather Y F Yong et al. Curr Opin Neurol. .

Abstract

Purpose of review: This review offers a contemporary clinical approach to the diagnosis of viral encephalitis and discusses recent advances in the field. The neurologic effects of coronaviruses, including COVID-19, as well as management of encephalitis are not covered in this review.

Recent findings: The diagnostic tools for evaluating patients with viral encephalitis are evolving quickly. Multiplex PCR panels are now in widespread use and allow for rapid pathogen detection and potentially reduce empiric antimicrobial exposure in certain patients, while metagenomic next-generation sequencing holds great promise in diagnosing challenging and rarer causes of viral encephalitis. We also review topical and emerging infections pertinent to neuroinfectious disease practice, including emerging arboviruses, monkeypox virus (mpox), and measles.

Summary: Although etiological diagnosis remains challenging in viral encephalitis, recent advances may soon provide the clinician with additional tools. Environmental changes, host factors (such as ubiquitous use of immunosuppression), and societal trends (re-emergence of vaccine preventable diseases) are likely to change the landscape of neurologic infections that are considered and treated in clinical practice.

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References

    1. Venkatesan A, Tunkel AR, Bloch KC, et al. Case definitions, diagnostic algorithms, and priorities in encephalitis: consensus statement of the international encephalitis consortium. Clin Infect Dis 2013; 57:1114–1128.
    1. Steiner I, Budka H, Chaudhuri A, et al. Viral encephalitis: a review of diagnostic methods and guidelines for management. Eur J Neurol 2005; 12:331–343.
    1. Wang H, Zhao S, Wang S, et al. Global magnitude of encephalitis burden and its evolving pattern over the past 30 years. J Infect 2022; 84:777–787.
    1. Singh TD, Fugate JE, Rabinstein AA. The spectrum of acute encephalitis: causes, management, and predictors of outcome. Neurology 2015; 84:359–366.
    1. Venkatesan A. Epidemiology and outcomes of acute encephalitis. Curr Opin Neurol 2015; 28:277–282.