Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Dec;33(8):3347-3355.
doi: 10.1007/s00590-023-03548-4. Epub 2023 Apr 20.

Sequential repeated tibial tubercle osteotomy in a two-stage exchange strategy: a superior approach to treating a chronically infected knee arthroplasty?

Pablo S Corona #  1   2   3 , Marta Pérez #  4   5 , Matías Vicente  1   2   3 , Oriol Pujol  1 , Carles Amat  1   2   3 , Lluís Carrera  1   2   3   6
Affiliations

Sequential repeated tibial tubercle osteotomy in a two-stage exchange strategy: a superior approach to treating a chronically infected knee arthroplasty?

Pablo S Corona et al. Eur J Orthop Surg Traumatol. 2023 Dec.

Abstract

Purpose: Surgical approach can impact the reliability of the debridement after a chronic total knee periprosthetic joint infection (PJI), a factor of utmost importance to eradicate the infection. The most adequate knee surgical approach in cases of PJI is a matter of debate. The purpose of this study was to determine the influence of performing a tibial tubercle osteotomy (TTO) in a two-stage exchange protocol for knee PJI treatment.

Methods: Retrospective cohort study examining patients managed with two-stage arthroplasty due to chronic knee PJI (2010-2019). Performance and timing of the TTO were collected. Primary end-point was infection control with a minimum FU of 12 months and according to internationally accepted criteria. Correlation between TTO timing and reinfection rate was reviewed.

Results: Fifty-two cases were finally included. Overall success (average follow-up: 46.2 months) was 90.4%. Treatment success was significantly higher among cases addressed using TTO during the second stage (97.1% vs. 76.5%, p value 0.03). Only 4.8% of the patients relapsed after performing a sequential repeated TTO, that is, during both first and second stages, compared to 23.1% cases in which TTO was not done (p value 0.28). No complications were observed among patients in the TTO group with a significant decrease in soft tissue necrosis (p: 0.052).

Conclusion: Sequential repeated tibial tubercle osteotomy during a two-stage strategy is a reasonable option and offers high rates of infection control in complex cases of knee PJI with a low rate of complications.

Keywords: Infection control; Periprosthetic joint infection; Tibial tubercle osteotomy; Two-stage revision arthroplasty.

PubMed Disclaimer

Conflict of interest statement

All Authors: None of the authors received payments or services, either directly or indirectly (i.e., via his or her institution), from a third party in support of any aspect of this work. One of the authors (Pablo S. Corona) has done paid speaking engagements at scientific conferences during the thirty-six months prior to submission of this work, to an entity in the biomedical arena (Tecres SpA, Sommacampagna–VR, Italy and Waldemar Link GmbH & Co.; Germany) whose products have been mentioned in the article. The author does not have any other conflict of interest with said companies. No author has had any other relationships, or has engaged in any other activities that could be perceived to influence or have the potential to influence what is written in this work.

Figures

Fig. 1
Fig. 1
a First stage tibial tubercle osteotomy (TTO) approach. The cerclages pass behind the spacer stem; b anteroposterior and c lateral radiography of a prefabricated mobile spacer
Fig. 2
Fig. 2
a First stage tibial tubercle osteotomy (TTO) approach with a static spacer; b anteroposterior radiography of the static spacer
Fig. 3
Fig. 3
a Anteroposterior and b lateral post-operative radiography showing an Endo-Model®-M knee revision prosthesis
Fig. 4
Fig. 4
Flowchart of study cases. MSIS, Musculoskeletal Infection Society
Fig. 5
Fig. 5
Kaplan–Meier curve. Probability of infection control depending on approach during second stage
See this image and copyright information in PMC

References

    1. Bozic KJ, Kurtz SM, Lau E, Ong K, Chiu V, Vail TP, et al. The epidemiology of revision total knee arthroplasty in the United States. Clin Orthop. 2010;468(1):45–51. doi: 10.1007/s11999-009-0945-0. - DOI - PMC - PubMed
    1. Lichstein P, Gehrke T, Lombardi A, Romano C, Stockley I, Babis G, et al. One-stage versus two-stage exchange. J Orthop Res. 2014;32(Suppl 1):S141–146. doi: 10.1002/jor.22558. - DOI - PubMed
    1. Insall JN. Infection in total knee arthroplasty. Instr Course Lect. 1982;31:42–48. - PubMed
    1. Corró S, Vicente M, Rodríguez-Pardo D, Pigrau C, Lung M, Corona PS. Vancomycin-Gentamicin prefabricated spacers in 2-stage revision arthroplasty for chronic hip and knee periprosthetic joint infection: insights into reimplantation microbiology and outcomes. J Arthroplasty. 2020;35(1):247–254. doi: 10.1016/j.arth.2019.07.043. - DOI - PubMed
    1. Corona PS, Barro V, Mendez M, Cáceres E, Flores X. Industrially prefabricated cement spacers: do Vancomycin- and gentamicin-impregnated spacers offer any advantage? Clin Orthop Relat Res. 2014;472(3):923–932. doi: 10.1007/s11999-013-3342-7. - DOI - PMC - PubMed

MeSH terms