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. 2023 Aug 1;42(8):e290-e292.
doi: 10.1097/INF.0000000000003938. Epub 2023 Apr 27.

Use of Monoclonal Antibodies in a Pediatric Patient With Severe Combined Immunodeficiency and Persistent SARS-CoV-2 Infection

Amanda Bermejo-Gómez  1 , David Aguilera-Alonso  1   2 , Elena María Rincón-López  1   2 , Pilar Catalán-Alonso  3 , Eduardo J Bardón-Cancho  4 , Marina García-Morín  4 , Silvia Manrique-Rodríguez  5 , María Luisa Navarro-Gómez  1   2
Affiliations

Use of Monoclonal Antibodies in a Pediatric Patient With Severe Combined Immunodeficiency and Persistent SARS-CoV-2 Infection

Amanda Bermejo-Gómez et al. Pediatr Infect Dis J. .

Abstract

We describe the use of monoclonal antibodies for the treatment of persistent SARS-CoV-2 infection in a pediatric patient with severe combined immunodeficiency who required urgent stem cell transplantation to cure his disease.

Trial registration: ClinicalTrials.gov NCT04425629.

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Conflict of interest statement

The authors have no funding or conflicts of interest to disclose.

Figures

FIGURE 1.
FIGURE 1.
Number 1 (day 0): PICU admission, intubation, diagnosis of SARS-CoV-2 infection, diagnosis and treatment of PJP pneumonia, diagnosis of SCID. Number 2 (day 40): extubation. Number 3 (day 62): remdesivir treatment. Number 4 (day 97): monoclonal antibody treatment. Number 5 (day 118): SCT. *Negative RT-PCR results are shown with Ct = 40. NPS indicates nasopharyngeal swab; PICU, pediatric intensive care unit; PJP, pneumocystis jirovecii pneumonia; RT-PCR, reverse transcriptase-polymerase chain reaction; SCID, severe combined immunodeficiency; SCT, stem cell transplantation. Figure created with Infogram app.
See this image and copyright information in PMC

References

    1. Meyts I, Bucciol G, Quinti I, et al. ; IUIS Committee of Inborn Errors of Immunity. Coronavirus disease 2019 in patients with inborn errors of immunity: an international study. J Allergy Clin Immunol. 2021;147:520–531. - PMC - PubMed
    1. Van Oers NSC, Hanners NW, Sue PK, et al. . SARS-CoV-2 infection associated with hepatitis in an infant with X-linked severe combined immunodeficiency. Clin Immunol. 2021;224:108662. - PMC - PubMed
    1. Hariharan SV, Muthusamy S, Asokan SK. Persistent viral shedding after sars-cov-2 infection in an infant with severe combined immunodeficiency. Indian J Pediatr. 2022;89:94. - PMC - PubMed
    1. Al-Saud B, Hazzazi KM, Mohammed R, et al. . SARS-CoV-2-related acute respiratory distress syndrome uncovers a patient with severe combined immunodeficiency disease. J Clin Immunol. 2021;41:1507–1510. - PMC - PubMed
    1. Keitel V, Bode JG, Feldt T, et al. . Case report: convalescent plasma achieves SARS-CoV-2 viral clearance in a patient with persistently high viral replication over 8 weeks due to severe combined immunodeficiency (scid) and graft failure. Front Immunol. 2021;12:645989. - PMC - PubMed

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