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Review
. 2024 Feb;40(1):337-348.
doi: 10.1007/s12028-023-01725-1. Epub 2023 Apr 20.

Crosstalk Between the Nervous System and Systemic Organs in Acute Brain Injury

Denise Battaglini #  1 , Silvia De Rosa #  2   3 , Daniel Agustin Godoy #  4
Affiliations
Review

Crosstalk Between the Nervous System and Systemic Organs in Acute Brain Injury

Denise Battaglini et al. Neurocrit Care. 2024 Feb.

Erratum in

Abstract

Organ crosstalk is a complex biological communication between distal organs mediated via cellular, soluble, and neurohormonal actions, based on a two-way pathway. The communication between the central nervous system and peripheral organs involves nerves, endocrine, and immunity systems as well as the emotional and cognitive centers of the brain. Particularly, acute brain injury is complicated by neuroinflammation and neurodegeneration causing multiorgan inflammation, microbial dysbiosis, gastrointestinal dysfunction and dysmotility, liver dysfunction, acute kidney injury, and cardiac dysfunction. Organ crosstalk has become increasingly popular, although the information is still limited. The present narrative review provides an update on the crosstalk between the nervous system and systemic organs after acute brain injury. Future research might help to target this pathophysiological process, preventing the progression toward multiorgan dysfunction in critically ill patients with brain injury.

Keywords: Brain organ interactions; Brain-gut crosstalk; Dysbiosis; Microbiota; Traumatic brain injury.

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