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. 2022 Oct-Dec;26(4):604.
doi: 10.4103/jomfp.jomfp_201_22. Epub 2022 Dec 22.

A study on genetic and mutans streptococcal transmissibility of dental caries

Shailja Chatterjee  1 , Satyawan G Damle  2 , Nageshwar Iyer  3
Affiliations

A study on genetic and mutans streptococcal transmissibility of dental caries

Shailja Chatterjee et al. J Oral Maxillofac Pathol. 2022 Oct-Dec.

Abstract

Background: Dental caries is characterized by an interplay between environmental and genetic factors.

Aim: The aim of this study was to analyse the transmissibilities of high caries risk chromosomal loci at 5q 12.1-13.3 and low caries risk chromosomal loci at 13q31.1 and Streptococcus mutans (S. mutans) in family units.

Materials: This prospective cohort study was performed on 56 families grouped into four: (a) Group I: 18 families of children with caries affected primary teeth; (b) Group II: 21 families of children with caries in permanent teeth; (c) Group III: 6 families of children with no caries in primary teeth and (d) Group IV: 12 families of children with no caries in permanent teeth. Blood, saliva and plaque samples were collected from consenting study participants. Isolated DNAs were subjected to polymerase chain reactions using suitable primers. Data collected was analysed with ANOVA and Chi-squared test.

Results: Wide expression of chromosome loci 5q12.1-13.3 was obtained in both blood and saliva samples. For chromosome loci 13q31.1, no expression was found in saliva samples, hence indicating its local absence. For the GtfB expression, transmissibility was common for a single band expressing S. mutans.

Conclusion: This study reflects upon newer findings in the field of genetic research on dental caries.

Keywords: 13q31.1; 5q12.1-13.3; GtfB; dental caries; genetic; transmissibility.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Chromosome 5q 12.1-13.3 expression in blood samples. On right is demonstrated labelling for different lanes with codes for individual family member
Figure 2
Figure 2
Chromosome 13q31.1 expression in blood sample. Towards right side is shown labelling for different lanes
Figure 3
Figure 3
1 bp band expression for GtfB in Streptococcus mutans
See this image and copyright information in PMC

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