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. 2022 Oct-Dec;26(4):602.
doi: 10.4103/jomfp.JOMFP_256_20. Epub 2022 Dec 22.

Significance and expression of p-Akt in oral squamous cell carcinoma

Suha Abdulhussein Hindy  1
Affiliations

Significance and expression of p-Akt in oral squamous cell carcinoma

Suha Abdulhussein Hindy. J Oral Maxillofac Pathol. 2022 Oct-Dec.

Abstract

Background: Oral cancer is considered as the sixth-most common malignant neoplasm in the world and the most common type is squamous cell carcinoma (SCC). Akt is a serine/threonine-protein kinase, that acts in the regulation of different signaling downstream pathways, including; proliferation, growth, cell metabolism, angiogenesis and survival. The objective of the present study was to show the expression of p-Akt and its prognostic effect in oral SCC (OSCC).

Materials and methods: A total of 72 cases of OSCC were included in this study; the expression of the Akt gene was done on 4 μm tumor sections using immunohistochemical staining of Akt antibody.

Results: Histopathological examination showed that: (43) were GIII, (13) cases were GII, and (16) cases were GI. The positivity of immunohistochemical staining were appear as brown stain. Results showed increase expression of p-Akt in most cases of oral SCC and mean expression about (54.86 ± 31.58), and the expression of p-Akt was increased with the progression of the histological grade of the tumor.

Conclusion: High expression of p-Akt and its relation with the progression of tumor grade and invasion of tumor may indicate the relationship between p-Akt expression and aggressiveness and progression of the tumor.

Keywords: Immunohistochemistry; Oral cancer; Oral squamous cell carcinoma; Phosphorylated Akt.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Expression of p-Akt in the epithelium of basal layer and in carcinomatous islands
Figure 2
Figure 2
Expression of p-Akt in well-differentiated squamous cell carcinoma
Figure 3
Figure 3
Expression of p-Akt in moderately differentiated squamous cell carcinoma demonstrate aberrant mitosis
Figure 4
Figure 4
Cytoplasmic expression of p-Akt in carcinomatous cells
Figure 5
Figure 5
Invasion islands of carcinomatous cells in the underlying tissue
Figure 6
Figure 6
Perineural invasion of carcinomatous cells
See this image and copyright information in PMC

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References

    1. Lim J, Kim JH, Paeng JY, Kim MJ, Hong SD, Lee JI, et al. Prognostic value of activated Akt expression in oral squamous cell carcinoma. J Clin Pathol. 2005;58:1199–205. - PMC - PubMed
    1. Malone JP, Stephens JA, Grecula JC, Rhoades CA, Ghaheri BA, Schuller DE. Disease control, survival and functional outcome after multimodal treatment for advanced – Stage tongue base cancer. J Head Neck. 2004;26:561–72. - PubMed
    1. Plame CE, Gullane PJ, Gilbert RW. Current treatment options in squamous cell carcinoma of the oral cavity. J Surg Oncol Clin N Am. 2004;13:47–70. - PubMed
    1. Nicholson KM, Anderson AG. The protein kinase B/Akt signaling pathway in human malignancy. J Cell Signal. 2002;14:381–95. - PubMed
    1. Hennessy BT, Smith DL, Ram PT, Lu Y, Mills GB. Exploiting the P13K/AKT pathway for cancer drug discovery. J Nat Rev Drug Discov. 2005;4:988–1004. - PubMed