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. 2022 Oct-Dec;26(4):592.
doi: 10.4103/jomfp.jomfp_324_21. Epub 2022 Dec 22.

Assessment of the anti-oxidant reduced glutathione in oral squamous cell carcinoma - Systematic review and meta-analysis

Khadijah Mohideen  1 , Uma Sudhakar  2 , Nadeem Jeddy  3 , S Leena Sankari  4 , T Radhika  3 , N Vani  5
Affiliations

Assessment of the anti-oxidant reduced glutathione in oral squamous cell carcinoma - Systematic review and meta-analysis

Khadijah Mohideen et al. J Oral Maxillofac Pathol. 2022 Oct-Dec.

Abstract

Background: The excess reactive oxygen species or free radicals reaction leads to oxidative injury to the biological components such as cells and tissues, which would result in the initiation and progression of carcinogenesis. The magnitude of oxidative damage depends primarily on the balance between free radicals (pro-oxidants) and antioxidant system activity.

Aim: To assess antioxidant status by evaluating the reduced glutathione (GSH) levels in various biological samples of patients with oral squamous cell carcinoma (OSCC) using available literature.

Materials and methods: An electronic literature search was carried out in PubMed (MeSH), Science Direct, Scopus and Cross Reference by using specific keywords.

Results: The systematic electronic search identified 704 articles. After studying the articles' titles and abstracts, 657 articles were excluded for the following reasons; duplicated articles, animal studies, studies of low quality and not relevant to the research question. The remaining 47 articles were selected for full-text assessment. After eliminating the articles that did not match the objectives, the present qualitative synthesis finally included 27 articles for evaluation. The ten studies, which showed coherent data, were included in quantitative analysis. The GSH levels in OSCC groups are significantly decreased (P < 0.001) in plasma and erythrocyte samples compared to healthy controls.

Conclusion: The selected studies showed significantly lower levels of GSH in various biological samples of OSCC. Hence, future studies are required to validate the expression of GSH as a prognostic biomarker in oral cancer.

Keywords: An antioxidant enzyme; oral cancer; oral squamous cell carcinoma; reduced glutathione.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Prisma flow chart – study selection
Figure 2
Figure 2
Forest plot shows standardized mean difference estimates with 95% confidence intervals representing differences in plasma levels of reduced glutathione between oral squamous cell carcinoma group and healthy controls
Figure 3
Figure 3
Forest plot shows standardized mean difference estimates with 95% confidence intervals representing differences in erythrocyte levels of reduced glutathione between oral squamous cell carcinoma group and healthy controls
See this image and copyright information in PMC

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