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Case Reports
. 2023 Feb;27(Suppl 1):S20-S23.
doi: 10.4103/jomfp.jomfp_260_22. Epub 2023 Feb 4.

Oral hibernoma along with multiple lipomas

Mahaboob Shahnaz  1 , Nair Shalini  1 , Abdul Qayyum Shereefa  1 , Kuruvilla Vikas  2
Affiliations
Case Reports

Oral hibernoma along with multiple lipomas

Mahaboob Shahnaz et al. J Oral Maxillofac Pathol. 2023 Feb.

Abstract

'Hibernoma' is a neoplasm that arises from vestiges of fetal brown fat, and its occurrence in oral cavity is extremely rare. Its most common locations include thighs, the inter-scapular region, and the cervical region. In the present case, a 37-year-old male patient reported to our department with a localized swelling on his lower left labial mucosa along with multiple cutaneous well-defined swellings on his right arm and abdominal region. Incisional biopsy was carried out. Histopathological examination revealed sheets of multi-vacuolated eosinophilic cells with the granular cytoplasm interspersed with fat cells suggestive of oral hibernoma. These are rare lesions and could be often a missed-out diagnosis. Therefore, it is imperative to consider oral hibernoma among the commonly considered differential diagnosis of oral mucosal swellings.

Keywords: Brown fat; S100 positivity; lipoma; oral hibernoma; rare benign tumour.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Clinical image showing well-defined localised swelling in the left lower labial mucosa having the same colour as that of the adjacent normal mucosa
Figure 2
Figure 2
Clinical image showing multiple well-defined swellings on the right upper arm region
Figure 3
Figure 3
Clinical image showing excisional biopsy that was carried out under local anaesthesia.
Figure 4
Figure 4
Grossing image showing a well-defined band of yellow matter along the course of the specimen in addition to other creamish and brownish areas
Figure 5
Figure 5
Histopathological image showing sheets of multi-vacuolated eosinophilic cells with a granular cytoplasm and eccentric nuclei interspersed with uni-vacuolated mature fat (H&E stain; 40X magnification)
Figure 6
Figure 6
Hand illustration depicting hibernoma. (A) Mature fat cells. (B) Hibernoma cells with a granular eosinophilic cytoplasm. (C) Connective tissue septa
Figure 7
Figure 7
Immuno-histochemical staining of lesional cells with S100 (IHC; 10Xmagnification)
See this image and copyright information in PMC

References

    1. Bajpai M, Pardhe N. Hibernoma of tongue-A rare case. J Coll Physicians Surg Pak. 2016;26:1003. - PubMed
    1. Thriveni R, Bhosle S, Ramesh DS, Praveen AH. Hibernoma: A rare benign tumor. J Indian Acad Oral Med Radiol. 2021;33:230–2.
    1. Da Motta AC, Tunkel DE, Westra WH, Yousem DM. Imaging findings of a hibernoma of the neck. AJNR Am J Neuroradiol. 2006;27:1658–9. - PMC - PubMed
    1. Mavrogenis AF, Coll-Mesa L, Drago G, Gambarotti M, Ruggieri P. Hibernomas: Clinicopathological features, diagnosis, and treatment of 17 cases. Orthopedics. 2011;34:e755–9. - PubMed
    1. Veger HT, Ravensbergen NJ, Ottenhof A, da Costa SA. Familial multiple lipomatosis: A case report. Acta Chir Belg. 2010;110:98–100. - PubMed

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