PARP inhibitors, use early in the first-line maintenance therapy setting but with caution
- PMID: 37082675
- PMCID: PMC10113106
- DOI: 10.21037/atm-2022-81
PARP inhibitors, use early in the first-line maintenance therapy setting but with caution
Keywords: Poly-(ADP-ribose) polymerase (PARP) inhibitors (PARPis); biomarker-guided cancer treatment; mechanism of drug resistance; optimal sequencing for cancer treatment.
Conflict of interest statement
Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://atm.amegroups.com/article/view/10.21037/atm-2022-81/coif). JML received grant (No. ZIA BC011525) from National Cancer Institute Center for Cancer Research (NCI CCR) and National Institutes of Health. The other authors have no conflicts of interests to declare.
Comment on
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A Randomized, Phase III Trial to Evaluate Rucaparib Monotherapy as Maintenance Treatment in Patients With Newly Diagnosed Ovarian Cancer (ATHENA-MONO/GOG-3020/ENGOT-ov45).J Clin Oncol. 2022 Dec 1;40(34):3952-3964. doi: 10.1200/JCO.22.01003. Epub 2022 Jun 6. J Clin Oncol. 2022. PMID: 35658487 Free PMC article. Clinical Trial.
References
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- Pujade-Lauraine E, Ledermann JA, Selle F, et al. Olaparib tablets as maintenance therapy in patients with platinum-sensitive, relapsed ovarian cancer and a BRCA1/2 mutation (SOLO2/ENGOT-Ov21): a double-blind, randomised, placebo-controlled, phase 3 trial. Lancet Oncol 2017;18:1274-84. 10.1016/S1470-2045(17)30469-2 - DOI - PubMed
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