doi: 10.1016/0006-8993(86)90819-x.
Nicotinic acetylcholine binding sites in Alzheimer's disease
- PMID: 3708340
- DOI: 10.1016/0006-8993(86)90819-x
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Nicotinic acetylcholine binding sites in Alzheimer's disease
Brain Res.
.
Abstract
In Alzheimer's disease (AD), there is a loss of presynaptic cholinergic markers in the cerebral cortex, but the nature of cholinergic receptor changes is unclear. In this study, [3H]acetylcholine and [3H]nicotine were used to label nicotinic cholinergic binding sites in cerebral cortical tissues obtained at autopsy from patients with AD and from matched controls. A consistent and severe loss of nicotinic receptors was found in AD.
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